Journal of Sol-Gel Science and Technology

, Volume 32, Issue 1–3, pp 201–205 | Cite as

Synthesis of Bioactive and Porous Organic-Inorganic Hybrids for Biomedical Applications

  • Kanji Tsuru
  • Satoshi Hayakawa
  • Akiyoshi Osaka


Bioactivity has been exhibited by a limited range of ceramics since the invention of Bioglass®. Recently, some bioactive polymeric organic-inorganic hybrids were introduced, including not only organically modified silicates (Ormosils) synthesized from polydimethylsiloxane (PDMS) and tetraethoxysilane but also those with gelatin and 3-glycidoxypropyl-tremethoxysilane. Preparation of the bulk and porous hybrids and their polymeric structures analyzed by Si NMR spectroscopy were presented. In vitro bioactivity or apatite deposition in a simulated body fluid of the Kokubo recipe were also described for those hybrids. Freeze-drying techniques introduced porosity (up to 90%) and pores extending in a preferred direction.


hybrids sol–gel process porosity biomedical applications 


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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  1. 1.Faculty of EngineeringOkayama UniversityOkayama-shiJapan

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