We prepared three types of Al2O3 with different surface structures and investigated 99Mo-adsorption/99mTc-elution properties using [99Mo]MoO3 that was irradiated in the Kyoto University Research Reactor. Al2O3 adsorbed [99Mo]molybdate ions in solutions at different pH; the lower was the pH, the higher was the Mo-adsorption capacity of Al2O3. The 99mTc-elution properties of molybdate ion adsorbed Al2O3 were elucidated by flowing saline. Consequently, it was suggested that 99Mo-adsorption/desorption properties are affected by the specific surface of Al2O3 and 99mTc-elution properties are affected by the crystal structure of Al2O3.
This is a preview of subscription content, access via your institution.
We’re sorry, something doesn't seem to be working properly.
Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.
OECD-NEA (2011) The supply of medical radioisotopes: an assessment of long-term global demand for technetium-99m. Nuclear Development
OECD-NEA (2011) the supply of medical radioisotopes: the path to reliability. Nuclear Development
OECD-NEA (2016) the supply of medical radioisotopes: 2016 medical isotope supply review: 99Mo/99mTc market demand and production capacity projection 2016–2021. Nuclear Development NEA/SEN/HLGMR(2016)2
Bradley E, et al (2010) iaea activities to support the transition of molybdenum-99 production away from the use of highly enriched uranium. RERTR 2010
Naik H et al (2013) An alternative route for the preparation of the medical isotope 99Mo from the 238U(γ, f) and 100Mo(γ, n) reactions. J Radioanal Nucl Chem 295:807–816
Gopalakrishna A et al (2016) Preparation of 99Mo from the 100Mo(γ, n) reaction and chemical separation of 99mTc. J Radioanal Nucl Chem 308:431–438
Tanase M et al (1997) A 99mTc generator using a new inorganic polymer adsorbent for (n, γ) 99Mo. Appl Radiat Isot 48:607–611
Chattopadhyay S et al (2017) Preparation of 99Mo/99mTc generator based on cross-linked chitosan polymer using low-specific activity (n, γ)99Mo. J Radioanal Nucl Chem 313:647–653
Saptiama I et al (2015) The use of sodium hypochlorite solution for (n, γ)99Mo/99mTc generator based on zirconium-based material (ZBM). Atom Indonesia 41:103–109
Chakravarty R et al (2012) Preparation of clinical-scale 99Mo/99mTc column generator using neutron activated low specific activity 99Mo and nanocrystalline γ-Al2O3 as column matrix. Nucl Med Biol 39:916–922
Saptiama I, Kaneti YV et al (2018) Template-free fabrication of mesoporous alumina nanospheres using post-synthesis water-ethanol treatment of monodispersed aluminium glycerate nanospheres for molybdenum adsorption. Small 14:1800474
Kadarisman K et al (2018) Synthesis of Nano-α-Al2O3 for 99Mo Adsorbent. At Indonesia 44:17–21
Munir M et al (2020) Development of mesoporous γ-alumina from aluminium foil waste for 99Mo/99mTc generator. J Radioanal Nucl Chem 326:87–96
Gitzen WH (1970) Alumina as a ceramic material. Wiley, Hoboken
Suzuki Y, Kitagawa T et al (2018) Molybdenum adsorption and desorption properties of alumina with different surface structures for 99Mo/99mTc Generators. Trans Mat Res Soc Jpn 43:75–80
Japan Radioisotope Association (2011) Isotope pocket data book, 11th edn. Tokyo
Kurosawa M, Shimizu K (1979) Estimation for production of molybdenum-99 using (n, γ) reaction. J At Energy Soc Jpn 21:505–509
Schmitt GL, Pietrzyk DJ (1985) liquid chromatographic separation of inorganic anions on an alumina column. Anal Chem 57:2247–2253
Jezlorowski H, Knözinger H (1979) Raman and ultraviolet spectroscopic characterization of molybdena on alumina catalysts. J Phys Chem 83:1166–1173
Oyerinde OF et al (2008) Solution structure of molybdic acid from Raman spectroscopy and DFT analysis. Inorg Chim Acta 361:1000–1007
Murata K, Ikeda S (1983) Studies on polynuclear molybdates in the aqueous solution by laser Raman spectroscopy. Spectrochim Acrta 39A:787–794
El Shafei GMS, Moussa NA, Philip CA (2000) Association of molybdenum ionic species with alumina surface. J Colloids Interface Sci 228:105–113
Kerkhof FPJM, Moulijn JA, Thomas R (1979) Laser-Raman spectroscopy of the alumina-supported rhenium oxide metathesis catalyst. J Catal 56:279–283
Steigman J (1982) Chemistry of the alumina column. Int J Appl Radiat Isot 33:829–834
This study was conducted as a part of the joint use study at the Institute for Integrated Radiation and Nuclear Science, Kyoto University.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Below is the link to the Supplementary Information.
About this article
Cite this article
Fujita, Y., Seki, M., Sano, T. et al. Effect on 99Mo-adsorption/99mTc-elution properties of alumina with different surface structures. J Radioanal Nucl Chem (2021). https://doi.org/10.1007/s10967-021-07616-z
- Mo adsorbent
- 99Mo/99mTc generator