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99Mo/99mTc generators based on aluminum molybdate gel matrix prepared by nano method

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Abstract

A procedure for preparation of 99Mo/99mTc radioisotope generator based on low specific activity neutron activated 99Mo was developed. Aluminum molybdate(VI)-99Mo of high Mo(VI) content (~ 364 mg/g Al99Mo) was prepared by mixing low specific activity molybdate(VI)-99Mo and aluminum mixture solution with isoamyl alcohol. Al99Mo gel matrix was precipitated when the pH of the mixture solution was raised to ~ 5 by addition of NaOH to the mixture. Radiometric measurements indicate the strong fixation of Molybdate(VI)-99Mo species in the form of the sparingly insoluble Al99Mo gel matrix. The prepared AlMo gel matrix was physiochemically characterized. Al99Mo gel matrix was used as a base material for preparation of 99Mo/99mTc generator. The 99mTc eluted from 99Mo/99mTc radioisotope generator was found to have relatively high elution yield (84 ± 2.3%), radionuclidic (≥ 99.99%), radiochemical (98.1 ± 0.9%) and chemical purity.

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Acknowledgements

The authors thank Prof. Dr. M. A. El-Absy for revising this work in this present form.

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Authors and Affiliations

  1. Radioactive Isotopes and Generators Department, Hot Labs. Center, Atomic Energy Authority, P. O. Box 13759, Cairo, Egypt

    M. Amin, M. A. El-Amir, H. E. Ramadan & H. El-Said

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  1. M. Amin
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  2. M. A. El-Amir
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  3. H. E. Ramadan
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  4. H. El-Said
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Correspondence to H. El-Said.

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Amin, M., El-Amir, M.A., Ramadan, H.E. et al. 99Mo/99mTc generators based on aluminum molybdate gel matrix prepared by nano method. J Radioanal Nucl Chem 318, 915–922 (2018). https://doi.org/10.1007/s10967-018-6141-5

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  • DOI: https://doi.org/10.1007/s10967-018-6141-5

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