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Recent developments in targeted imaging of CXCR4-chemokine receptor

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Abstract

Chemokine receptor 4 (CXCR4) have been over-expressed by multiple types of primary and metastatic cancer cells and organs. Accordingly, various types of small molecules, as well as, bio-molecules were employed for CXCR4 targeting for selective and efficient diagnosis and treatment of malignancies and diseases. Moreover, recent progresses in imaging modalities like SPECT, PET, and optical detection instruments have provided a promising perspective for the emergence of a potential detection and treatment by CXCR4 in desired tissues and organs. In this review, the reported CXCR4 targeted imaging agents are described based on their specificity, affinity and biodistribution.

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Acknowledgements

This work was supported by Tabriz University of Medical Sciences (Tabriz, Iran).

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Authors and Affiliations

  1. Medical Radiation Sciences Research Team, Tabriz University of Medical Sciences, Tabriz, Iran

    Ashraf Fakhari & Esmaeil Gharepapagh

  2. Research Centre for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran

    Ayuob Aghanejad

  3. Radioisotope Products and Radiation Technology Section, Department of Nuclear Sciences and Applications, International Atomic Energy Agency (IAEA), Vienna International Centre, PO Box 100, 1400, Vienna, Austria

    Amir Reza Jalilian

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  1. Ashraf Fakhari
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  2. Ayuob Aghanejad
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  3. Amir Reza Jalilian
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  4. Esmaeil Gharepapagh
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Correspondence to Ayuob Aghanejad.

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Fakhari, A., Aghanejad, A., Jalilian, A.R. et al. Recent developments in targeted imaging of CXCR4-chemokine receptor. J Radioanal Nucl Chem 317, 1–14 (2018). https://doi.org/10.1007/s10967-018-5910-5

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