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Journal of Radioanalytical and Nuclear Chemistry

, Volume 314, Issue 2, pp 1023–1029 | Cite as

Radiosynthesis and preclinical studies of 177Lu-labeled sulfadiazine: a possible theranostic agent for deep-seated bacterial infection

  • Syed Ali Raza Naqvi
  • Rashid Rasheed
  • Muhammad Tauqeer Ahmed
  • Ameer Fawad Zahoor
  • Muhammad Khalid
  • Sajid Mahmood
Article
  • 136 Downloads

Abstract

Sulfadiazine acts through inhibition of bacterial dihydropteroate synthetase. The radio-labeling of sulfadiazine with lutetium-177 (177Lu) is expected to serve as a theranostic agent for deep-seated bacterial infections. The radiosynthesis of 177Lu-sulfadiazine indicated a > 95% yield under optimized reaction conditions, and promising stability was found in blood serum. Biodistribution data in the absence of infection revealed minimal accumulation in key body organs. Kidneys were the main excretory organs, showed an uptake of 1.76 ± 0.09% ID/g organ at 6-h post-injection. Biodistribution, scintigraphic data, glomerular filtration rate, and cytotoxicity results encourage clinical investigation of 177Lu-sulfadiazine as a novel theranostic agent for deep-seated bacterial infection.

Keywords

Sulfadiazine Lutetium-177 177Lu-sulfadiazine Nuclear medicine Deep-seated infections 

Notes

Acknowledgements

The study is a part of HEC funded project No.5612/Punjab/NRPU/R&D/HEC/2016, thanks to HEC, GCU Faisalabad, PINSTECH Islamabad and INOR Abbottabad for providing resources, platform, and technical assistance to conduct this research. We are also thankful to Mr. Javid Gil (PINSTECH) for providing technical assistance in handling 177LuCl3. The authors are also grateful to Prof. Drlica Karl (USA) for editing and proof reading of the manuscript.

Compliance with ethical standards

Conflict of interest

There is no conflict of interest exist among all the authors.

Supplementary material

10967_2017_5477_MOESM1_ESM.tif (468 kb)
Supplementary material 1 (TIFF 467 kb)

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2017

Authors and Affiliations

  1. 1.Department of ChemistryGovernment College UniversityFaisalabadPakistan
  2. 2.Pakistan Institute of Nuclear Sciences and Technology (PINSTECH)IslamabadPakistan

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