Journal of Radioanalytical and Nuclear Chemistry

, Volume 314, Issue 2, pp 1177–1181 | Cite as

Radiochemical purity and stability of 99mTc-HMPAO in routine preparations

  • Licia Uccelli
  • Petra Martini
  • Micol Pasquali
  • Alessandra Boschi


The aim of this work was to investigate the influence of pH, recovery volume, type of saline solution plastic or glass container, used to prepare the technetium-99m-d,l-hexamethylpropyleneamineoxime ([99mTc]Tc-d,l-HMPAO] radiopharmaceutical starting from generator produced sodium pertechnetate in nuclear medicine routine preparations. We observed that, neither the container type, nor the pH of 0.9% NaCl, used for diluting the [99mTc]pertechnetate, influenced [99mTc]Tc-d,l-HMPAO radiochemical purity (RCP) and stability, that decreased proportionally with the final volume of the preparation. In particular, the RCP of 1 mL kits preparations, at 30 min was found to be less than 80%.


Technetium-99m-d,l-hexamethylpropyleneamineoxime Radiolabeling Brain imaging Radiochemical purity Radiopharmaceuticals 



Products are furnished by Nuclear Medicine Unit of University Hospital of Ferrara.


We declare that we have not received funding, contracts or other forms of personal or institutional funding, with companies whose products are mentioned in the text.


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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2017

Authors and Affiliations

  1. 1.Morphology, Surgery and Experimental Medicine DepartmentUniversity of FerraraFerraraItaly
  2. 2.Physics and Heart Science DepartmentUniversity of FerraraFerraraItaly
  3. 3.Legnaro National LaboratoriesItalian National Institute for Nuclear Physics (LNL-INFN)LegnaroItaly

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