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PLGA encapsulation and radioiodination of indole-3-carbinol: investigation of anticancerogenic effects against MCF7, Caco2 and PC3 cells by in vitro assays

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Abstract

Encapsulation with PLGA of I3C and radioiodination have been performed. Anticancerogenic effects of I3C and I3C-PLGA have been investigated utilizing in vitro methods on breast adenocarcinoma epithelial (MCF7), colon adenocarcinoma epithelial (Caco2), prostate carcinoma epithelial (PC3) cells. Characterization of I3C-PLGA have been performed with DLS method and SEM analysis. I3C and I3C-PLGA compounds have been radiolabeled in high yields with 131I which is widely used for diagnosis and treatment in Nuclear Medicine. All experimental results demonstrated that radioiodinated compounds are promising in order to be used in Nuclear Medicine as well as present study contributed previously reported studies.

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Acknowledgments

Current work is supported by Ege University Research Fund (Contract No 2014 NBE 003). The authors thank to Gökhan Takan for the technical assistance for graphing the particle size distribution of I3C-PLGA according to frequency of particles using GraphPad program (prism 2.01 V).

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Authors and Affiliations

  1. Institute of Nuclear Science, Ege University, Bornova, 35100, Izmir, Turkey

    Gorkem Yildiz, Ayfer Yurt Kilcar, E. Ilker Medine, Volkan Tekin, Ozge Kozgus Guldu & F. Zumrut Biber Muftuler

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  1. Gorkem Yildiz
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  2. Ayfer Yurt Kilcar
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  3. E. Ilker Medine
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  4. Volkan Tekin
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  6. F. Zumrut Biber Muftuler
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Correspondence to F. Zumrut Biber Muftuler.

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Yildiz, G., Yurt Kilcar, A., Medine, E.I. et al. PLGA encapsulation and radioiodination of indole-3-carbinol: investigation of anticancerogenic effects against MCF7, Caco2 and PC3 cells by in vitro assays. J Radioanal Nucl Chem 311, 1043–1052 (2017). https://doi.org/10.1007/s10967-016-4929-8

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  • DOI: https://doi.org/10.1007/s10967-016-4929-8

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