The distinction between chondroma and chondrosarcoma using chemical element mass fractions in tumors determined by neutron activation analysis as diagnostic markers

  • Vladimir Zaichick
  • Sofia Zaichick


The Ca, Cl, Mg, Na, and P content and Ca/P, Ca/Mg, Ca/Na, Cl/Ca, and Cl/Na ratios in tissue of intact bone, chondroma and chondrosarcoma were investigated by neutron activation analysis. It was shown that higher mass fraction of Cl and Na and also Cl/Na mass fraction ratio as well as lower Ca/Cl and Ca/Na mass fraction ratios are typical of the chondrosarcoma tissue compared to chondroma. Finally, it was proposed to use the estimation of such parameters as the Cl mass fraction and the Ca/Cl and Ca/Na mass fraction ratios as an additional test for differential diagnosis between chondroma and chondrosarcoma.


Chemical elements Human bone Chondroma Chondrosarcoma Neutron activation analysis 



We are grateful to the late Prof. V. A. Bizer, Medical Radiological Research Center, Obninsk, for supplying chondroma and chondrosarcoma samples.


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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2016

Authors and Affiliations

  1. 1.Radionuclide Diagnostics DepartmentMedical Radiological Research CentreObninskRussia
  2. 2.Department of MedicineUniversity of Illinois College of MedicineChicagoUSA

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