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Journal of Radioanalytical and Nuclear Chemistry

, Volume 309, Issue 2, pp 517–523 | Cite as

Evaluation of 18F-labeled icotinib derivatives as potential PET agents for tumor imaging

  • Hongyu Ren
  • Hongyu Ning
  • Jin Chang
  • Mingxia Zhao
  • Yong He
  • Yan Chong
  • Chuanmin Qi
Article

Abstract

In this study, three 18F-labeled crown ether fused anilinoquinazoline derivatives ([18F]11a–c) were synthesized and evaluated as potential tumor imaging probes. The biodistribution results of [18F]11b were good. Compared with [18F]-fludeoxyglucose and l-[18F]-fluoroethyltyrosine in the same animal model, [18F]11b had better tumor/brain, tumor/muscle, and tumor/blood uptake ratios. Overall, these results suggest that [18F]11b is promising as a tumor imaging agent for positron emission tomography.

Keywords

Quinazoline derivatives Biodistribution 18PET 

Notes

Acknowledgments

We conducted this work with financial support from The National Natural Science Foundation of China (No. 21071022) and the Fundamental Research Funds for the Central Universities. In addition, we would like to thank the cyclotron operator team of the PET center of Xuanwu Hospital for providing the fluoride-18 nuclide.

Supplementary material

10967_2015_4671_MOESM1_ESM.docx (136 kb)
Supplementary material 1 (DOCX 128 kb)

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2016

Authors and Affiliations

  • Hongyu Ren
    • 1
  • Hongyu Ning
    • 1
  • Jin Chang
    • 1
  • Mingxia Zhao
    • 1
  • Yong He
    • 1
  • Yan Chong
    • 1
  • Chuanmin Qi
    • 1
  1. 1.Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of ChemistryBeijing Normal UniversityBeijingPeople’s Republic of China

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