Synthesis of a theranostic agent: radioiodinated PEGylated PLGA-indocyanine capsules and in vitro determination of their bioaffinity on ovarian, cervical and breast cancer cells
The aim of current study is to synthesize a theranostic (multi-functional) agent, which is targeted on ovary, cervical and breast cancer types with diagnosis and treatment potential and to determine its bioaffinity by using in vitro methods. In conclusion; the designed compound (IPPP), which has fluorescence capability (from Indocyanine), encapsulated structure (with PEGylated PLGA), included an anticancer drug (Paclitaxel) for targeting and radionuclidic tracer (131I) content for tracing, has bioaffinity and promise for diagnosis and therapy on ovarian, cervical and breast cancer cell lines.
KeywordsIndocyanine Encapsulation 131I In vitro cell culture studies Paclitaxel
This work is supported by Ege University Research Fund (contract no 2014-TIP-085). The authors thank to Emine Derviş, Tansu Doğan, Ezgi Sulu, Onur Yıldız, Göksu Işık, Alper Kan and Büşra Karatay for the technical assistance during the in vitro experiments.
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