Radiosynthesis of 123I-labeled hesperetin for biodistribution study of orally administered hesperetin
- 214 Downloads
The purpose of this study is to synthesize 123I-labeled hesperetin and to investigate its in vivo behavior. The optimized labeling condition provided two isomers of 123I-labeled hesperetin with high radiochemical yields and radiochemical purities. Both 123I-labeled products were orally administered to normal ICR mice, and the initial result showed that most of 123I activity was detected in the stomach and the intestines. A part of 123I-labeled hesperetin was absorbed from the small intestine to bloodstream and then it was distributed in normal organs. The results in the present study provided an efficient radiolabeling method of flavonoid and quantitative organ distribution of orally administered hesperetin.
KeywordsHesperetin Radiolabeling Biodistribution SPECT/CT
This work was supported by the National Research Foundation of Korea grant funded by the Korea government (Grant Nos. 2012M2B2B1055245 and 2012M2A2A6011335) and Korea Atomic Energy Research Institute.
- 7.Kanaza FI, Bounartzi MI, Georgarakis M, Niopas I (2007) Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects. Eur J Clin Nutr 61(4):472–477Google Scholar
- 10.Srirangam R, Hippalgaonkar K, Avula B, Khan IA, Majumdar S (2012) Evaluation of the intravenous and topical routes for ocular delivery of hesperidin and hesperetin. J Ocul Pharmacol Ther 28(6):618–627Google Scholar
- 13.Kim SK, Ham I, Bu Y, Kim H, Cho JH, Choi H (2008) Study on the attributive channel theory of herbal medicine by the pharmacodynamics research of I-131 labelled hesperetin. Korea J Herbol 23(1):117–125Google Scholar