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Journal of Radioanalytical and Nuclear Chemistry

, Volume 306, Issue 2, pp 437–443 | Cite as

Radiosynthesis of 123I-labeled hesperetin for biodistribution study of orally administered hesperetin

  • Jongho Jeon
  • So-Young Ma
  • Dae Seong Choi
  • Beom-Su Jang
  • Jung Ae Kang
  • You Ree Nam
  • Seonhye Yoon
  • Sang Hyun Park
Article

Abstract

The purpose of this study is to synthesize 123I-labeled hesperetin and to investigate its in vivo behavior. The optimized labeling condition provided two isomers of 123I-labeled hesperetin with high radiochemical yields and radiochemical purities. Both 123I-labeled products were orally administered to normal ICR mice, and the initial result showed that most of 123I activity was detected in the stomach and the intestines. A part of 123I-labeled hesperetin was absorbed from the small intestine to bloodstream and then it was distributed in normal organs. The results in the present study provided an efficient radiolabeling method of flavonoid and quantitative organ distribution of orally administered hesperetin.

Keywords

Hesperetin Radiolabeling Biodistribution SPECT/CT 

Notes

Acknowledgments

This work was supported by the National Research Foundation of Korea grant funded by the Korea government (Grant Nos. 2012M2B2B1055245 and 2012M2A2A6011335) and Korea Atomic Energy Research Institute.

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2015

Authors and Affiliations

  • Jongho Jeon
    • 1
  • So-Young Ma
    • 1
  • Dae Seong Choi
    • 1
  • Beom-Su Jang
    • 1
  • Jung Ae Kang
    • 1
  • You Ree Nam
    • 1
  • Seonhye Yoon
    • 1
  • Sang Hyun Park
    • 1
    • 2
  1. 1.Advanced Radiation Technology Institute, Korea Atomic Energy Research InstituteJeongeupRepublic of Korea
  2. 2.Department of Radiation Biotechnology and Applied Radioisotope ScienceKorea University of Science and TechnologyDaejeonRepublic of Korea

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