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Journal of Radioanalytical and Nuclear Chemistry

, Volume 304, Issue 3, pp 1285–1291 | Cite as

Preparation and biological evaluation of 166Ho-BPAMD as a potential therapeutic bone-seeking agent

  • Hassan Yousefnia
  • Naeimeh Amraei
  • Mohammad Hosntalab
  • Samaneh Zolghadri
  • Ali Bahrami-Samani
Article

Abstract

In this work 166Ho-(4-{[(bis(phosphonomethyl))carbamoyl]methyl}-7,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl) acetic acid (166Ho-BPAMD) complex was prepared successfully with sufficient radiochemical purity of >94 % and specific activity of 244 GBq/mmol at the optimized conditions. The complex demonstrated significant stability at room temperature and in human serum at least for 24 h. Hydroxyapatite (HA) binding assay demonstrated that even at the small amount of HA, >10 mg, above 98 % of the complex is bound to HA. At the pH 7.4, LogP0/w was −1.73 ± 0.02. Both planar imaging and biodistribution studies showed major accumulation of the labelled compound in the bone tissue.

Keywords

166Ho BPAMD Bone marrow ablation Scintigraphy Biodistribution 

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2015

Authors and Affiliations

  • Hassan Yousefnia
    • 1
  • Naeimeh Amraei
    • 2
  • Mohammad Hosntalab
    • 2
  • Samaneh Zolghadri
    • 1
  • Ali Bahrami-Samani
    • 1
  1. 1.Nuclear Science and Technology Research Institute (NSTRI)TehranIran
  2. 2.Faculty of Engineering, Science and Research BranchIslamic Azad University (IAU)TehranIran

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