Single vial kit formulation for preparation of PET radiopharmaceutical: 68Ga-DOTA-TOC
- 284 Downloads
This paper describes the development of a lyophilized cold kit of DOTA-[Tyr3]-Octreotide (DOTA-TOC) for instant compounding of 68Ga-DOTA-TOC, suitable for diagnosis of neuroendocrine tumors. The work involved formulation of DOTA-TOC kits, optimization of radiolabeling, quality control of 68Ga-DOTA-TOC and animal biodistribution studies. The prepared kits enable a reliable method for preparation of 68Ga-DOTA-TOC of high radiochemical purity and excellent stability. Availability of such kits along with 68Ge/68Ga generators is expected to stimulate the widespread use of 68Ga-DOTA-TOC in nuclear medicine practice in developing countries.
Keywords68Ge/68Ga generator 68Ga-DOTA-[Tyr3]-octreotide Lyophilized cold kit PET imaging
Research at the Bhabha Atomic Research Centre (BARC) is part of the ongoing activities of the Department of Atomic Energy, India, and is fully supported by government funding. The authors express their sincere thanks to Dr. M.R.A. Pillai, former Head, Radiopharmaceuticals Division, BARC for initiating this work. The authors are thankful to Dr. K.L. Ramakumar, Director (I), RC& I Group, BARC for encouragement and support.
- 23.Maecke HR, Andrè JP (2007) In: Schubiger PA, Lehmann L, Friebe M (eds) PET chemistry—the driving force in molecular imaging series. Proceedings of the ernst schering foundation symposium, Springer, Berlin, p 215Google Scholar
- 25.Mukherjee A, Korde A, Sarma HD, Samuel G (2014). doi: 10.1007/s10967-014-3308-6