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Single vial kit formulation for preparation of PET radiopharmaceutical: 68Ga-DOTA-TOC

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Abstract

This paper describes the development of a lyophilized cold kit of DOTA-[Tyr3]-Octreotide (DOTA-TOC) for instant compounding of 68Ga-DOTA-TOC, suitable for diagnosis of neuroendocrine tumors. The work involved formulation of DOTA-TOC kits, optimization of radiolabeling, quality control of 68Ga-DOTA-TOC and animal biodistribution studies. The prepared kits enable a reliable method for preparation of 68Ga-DOTA-TOC of high radiochemical purity and excellent stability. Availability of such kits along with 68Ge/68Ga generators is expected to stimulate the widespread use of 68Ga-DOTA-TOC in nuclear medicine practice in developing countries.

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Acknowledgments

Research at the Bhabha Atomic Research Centre (BARC) is part of the ongoing activities of the Department of Atomic Energy, India, and is fully supported by government funding. The authors express their sincere thanks to Dr. M.R.A. Pillai, former Head, Radiopharmaceuticals Division, BARC for initiating this work. The authors are thankful to Dr. K.L. Ramakumar, Director (I), RC& I Group, BARC for encouragement and support.

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Authors and Affiliations

  1. Isotope Production & Applications Division, Bhabha Atomic Research Centre, 400085, Mumbai, India

    Archana Mukherjee, Usha Pandey, Rubel Chakravarty & Ashutosh Dash

  2. Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, 400085, Mumbai, India

    Haladhar Dev Sarma

Authors
  1. Archana Mukherjee
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  2. Usha Pandey
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  3. Rubel Chakravarty
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  4. Haladhar Dev Sarma
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  5. Ashutosh Dash
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Correspondence to Ashutosh Dash.

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Mukherjee, A., Pandey, U., Chakravarty, R. et al. Single vial kit formulation for preparation of PET radiopharmaceutical: 68Ga-DOTA-TOC. J Radioanal Nucl Chem 302, 1253–1258 (2014). https://doi.org/10.1007/s10967-014-3643-7

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  • DOI: https://doi.org/10.1007/s10967-014-3643-7

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