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Evaluation of 153Sm/177Lu-EDTMP mixture in wild-type rodents as a novel combined palliative treatment of bone pain agent

  • Hassan Ranjbar
  • Ali Bahrami-Samani
  • Davood Beiki
  • Simindokht Shirvani-Arani
  • Mohammad Ghannadi-Maragheh
Article

Abstract

In this work, the cocktail complex 153Sm/177Lu-EDTMP was prepared in high radiochemical purity (more than 99 %) using in house synthesized EDTMP ligand for obtaining a possible synergistic wide range palliative agent. The mixture was administered to wild-type rats and biodistribution data collected after 2 h to 7 days showed at least 70 % accumulation of the radioactivity in the bone tissues. Scintigraphic images were taken from wild-type rats injected with 153Sm/177Lu-EDTMP after 24 h and the biodistribution was shown to be consistent with post-mortem data. A comparative accumulation study was performed for vital organs up to 7 days. 153Sm/177Lu-EDTMP seemed a promising agent for bone pain palliation therapy in skeletal metastases in humans as a novel combined radiopharmaceutical.

Keywords

153Sm/177Lu-EDTMP Combined radiopharmaceutical Biodistribution Pain palliation Bone metastases 

Notes

Acknowledgements

Authors wish to thank Tehran Research Reactor colleagues for their support and Mr. M. Mazidi for conducting animal studies.

Conflicts of interest

The authors report no conflicts of interest in this work.

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2014

Authors and Affiliations

  • Hassan Ranjbar
    • 1
  • Ali Bahrami-Samani
    • 1
  • Davood Beiki
    • 2
  • Simindokht Shirvani-Arani
    • 1
  • Mohammad Ghannadi-Maragheh
    • 1
  1. 1.Radiopharmaceutical Research and Development Lab (RRDL)Nuclear Science and Technology Research Institute (NSTRI)TehranIran
  2. 2.Research Center for Nuclear MedicineTehran University of Medical SciencesTehranIran

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