Biodistribution of 99mTc–2-aminoestrone-3-methyl ether as a potential radiotracer for inflammation imaging
Estrogens may have pro- and anti-inflammatory properties depending on the situation and the involved tissue. 2-Aminoestrone-3-methyl ether as an estrogenic derivative was prepared with a yield of 55 % and well characterized. 99mTc–2-aminoestrone-3-methyl ether radiotracer was synthesized to study its inflammatory binding specificity as a novel selective radiopharmaceutical for inflammation imaging. In-vivo biodistribution study of 99mTc–2-amino estrone-3-methyl ether complex in both bacterial infection and sterile inflammation showed high and rapid accumulation of 99mTc–2-aminoestrone-3-methyl ether complex at the site of sterile inflammation compared to bacterial infection sites (target-to-non target ratio equal to 4.12 ± 0.02). This high biological accumulation in inflamed cells suggests that 99mTc–2-aminoestrone-3-methyl ether complex may be suitable as a potential selective radiotracer able to image inflammatory sites.
KeywordsEstrone Technetium-99m Inflammation Imaging
This research project was supported by a grant from the “Research Center of Female Scientific and Medical Colleges”, Deanship of Scientific Research, King Saud University.
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