Radiosynthesis and biological evaluation of 166Ho labeled methoxylated porphyrins as possible therapeutic agents
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166Ho labeled 5,10,15,20-tetrakis(3,4-dimethoxyphenyl) porphyrin, and 5,10,15,20-tetrakis(3,4,5-trimethoxyphenyl) porphyrin ([166Ho]–TDMPP and [166Ho]–TTMPP respectively) were prepared with acceptable radiochemical purity and specific activities. Stability and partition coefficient of the complexes were determined in the final formulations and biodistribution studies in mouse demonstrated high accumulation of [166Ho]–TDMPP in the lung and liver and less excretion through the kidney. while [166Ho]–TTMPP was mostly excreted into intestines and kidneys while lungs were a minor accumulation site. In contrast to other reported radiolanthanide labeled porphyrins these two complexes showed less liver accumulation. Further investigation of their potential therapeutic properties is of interest.
KeywordsMethoxylated porphyrins 166Ho Biodistribution Cancer therapy
Authors wish to thank Deputy of the Research of Tehran University of Medical Sciences for the financial support of this project and also special thanks to Mr M. Mazidi for performing animal studies as well as Dr. M. Erfani and Ms. F. Bolouroinovin for performing analytical experiments.
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