Journal of Radioanalytical and Nuclear Chemistry

, Volume 292, Issue 3, pp 1411–1415 | Cite as

Polymer-coated magnetic nanoparticles for rapid bioassay of 90Sr in human urine samples

  • Zack Varve
  • Edward P. C. Lai
  • Chunsheng Li
  • Baki B. Sadi
  • Gary H. Kramer


A rapid bioassay for 90Sr was developed involving preconcentration of 90Sr/90Y from human urine samples with a cation exchange polymer (poly–acrylamido–methyl–propanesulfonic acid) coated onto magnetic nanoparticles, followed by selective elution of 90Sr (over 90Y) with phosphate for determination by liquid scintillation analysis. The minimum detectable activity for this method (4.9 ± 0.5 Bq/L) is lower than the required sensitivity of 19 Bq/L for 90Sr in human urine samples, as defined in the requirements for radiation emergency bioassay techniques for the public and first responders based on the dose threshold for possible medical attention recommended by the International Commission on Radiological Protection. The relative bias was 9.2%, the relative precision was 3.2%, and the linear dynamic range covered 12–600 Bq/L. This simple and rapid bioassay method is found to be in compliance with the HPS ANSI N13.30 performance criteria for radiobioassay.


90Sr 90Human urine Magnetic nanoparticles Polymer coating Phosphate elution Liquid scintillation counting Bioassay 



This project is part of the CRTI06-230RD research program on Rapid Methods for Emergency Radiobioassay.


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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2012

Authors and Affiliations

  • Zack Varve
    • 1
  • Edward P. C. Lai
    • 1
  • Chunsheng Li
    • 2
  • Baki B. Sadi
    • 2
  • Gary H. Kramer
    • 2
  1. 1.Department of ChemistryCarleton UniversityOttawaCanada
  2. 2.Radiation Protection BureauHealth CanadaOttawaCanada

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