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Bioevaluation of 99mTc(CO)3–Guanine in vitro and in vivo

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Abstract

The aim of this study is to examine biological behaviour of radiolabeled guanine with [Tc(CO)3]+ core in vitro and in vivo. In vitro biological behavior of 99mTc(CO)3–Gua was evaluated on Lung (A-549), Breast (MCF-7), Colonic (Caco) carcinoma cell lines and normal human bronchial epithelial (NHBE). 99mTc(CO)3–Gua compound showed high uptake on A-549 cell line when compared to NHBE cell line. Biodistribution characteristics of 99mTc(CO)3–Gua was evaluated using New Zeland Rabbits. Scintigraphic results showed that a high level of radioactivity was observed in the lungs and liver shortly after administration of the 99mTc(CO)3–Gua and excretion takes place via both renal and hepatobiliary route. It was concluded that 99mTc(CO)3–Gua could be used as a nucleotide radiopharmaceutical for imaging purposes.

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Authors and Affiliations

  1. Institute of Nuclear Sciences, Ege University, 35100, İzmir, Turkey

    Çiğdem İçhedef, Serap Teksöz, Perihan Ünak, Kamile Şenocak & Emin İ. Medine

  2. Department of Nuclear Medicine, School of Medicine, Dokuz Eylul University, Inciralti İzmir, Turkey

    Türkan Ertay & Recep Bekiş

Authors
  1. Çiğdem İçhedef
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  2. Serap Teksöz
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  3. Perihan Ünak
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  4. Kamile Şenocak
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  5. Emin İ. Medine
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  6. Türkan Ertay
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  7. Recep Bekiş
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Correspondence to Serap Teksöz.

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İçhedef, Ç., Teksöz, S., Ünak, P. et al. Bioevaluation of 99mTc(CO)3–Guanine in vitro and in vivo. J Radioanal Nucl Chem 292, 739–743 (2012). https://doi.org/10.1007/s10967-011-1493-0

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  • DOI: https://doi.org/10.1007/s10967-011-1493-0

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