Skip to main content
Log in

Selenium and vitamin E concentrations in human milk and formula milk from Hungary

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

The metabolic roles of vitamin E and selenium are closely related, and to a very great extent, each can compensate for the deficiency of the other. The aim of the study was to determine and compare the Se and vitamin E (α- and γ-tocopherol) contents of breast milk and commercially available infant formulas in Hungary. The Se content was measured by instrumental neutron activation analysis (INAA), while the α-, and γ-tocopherol concentrations were determined by high performance liquid chromatography (HPLC). The mean Se concentration was 17.4±2.8 μg/L in transitional and 13.8±2.3 μg/L in mature milk. It was found that, all of the starter (ST), the follow-on (FO) and the specialized formulas (SF) had lower Se content than breast milk. Transitional breast milk resulted in a higher Se intake (14 μg/day) than mature milk (11 μg/day). The daily Se intakes in Hungarian infants were within the Recommended Dietary Allowance (RDA) range. The natural vitamin E contents of human milk were similar during the early and late lactation. Mature breast milk had 3.30±1.13 mg/L α-TE concentration and this was significantly higher than that of in ST (1.98±1.57), and FO (1.77±0.78), or in SF ready to feed preparations (1.03±0.74). The present study suggests that the formulas for the optimal development of young infants, should contain concentrations of these antioxidants on a level which is comparable to that of the human milk.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. I. Lombeck, K. Kasparek, H. D. Harbisch, L. E. Feinendegen, H. J. Bremer, Eur. J. Pediatr., 125 (1977) 81.

    Article  CAS  Google Scholar 

  2. J. G. Dorea, Br. J. Nutr., 88 (2002) 443.

    Article  CAS  Google Scholar 

  3. G. F. Combs, Br. J. Nutr., 85 (2001) 517.

    Article  CAS  Google Scholar 

  4. P. Bratter, V. E. Negretti de Bratter, U. Rösick, H. B. von Stockhausen, in: Trace Elements in the Nutrition of Children, Vol. 23, Vevey/Raven Press Ltd., New York, 1991, p. 79.

    Google Scholar 

  5. F. Jochum, A. Fuchs, M. Á. Cser, H. Menzel, I. Lombeck, Analyst, 120 (1995) 905.

    Article  CAS  Google Scholar 

  6. E. Sievers, T. Arpe, U. Schleyerbach, D. Garbe-Schonberg, J. Schaub, J. Trace Elem. Med. Biol., 14 (2001) 218.

    Article  CAS  Google Scholar 

  7. O. A. Levander, Ann. New York Acad. Sci., 393 (1982) 70.

    Article  CAS  Google Scholar 

  8. E. M. Ostrea, J. E. Balun, R. Winkler, T. Porter, Am. J. Obstet. Gynecol., 154 (1986) 1014.

    CAS  Google Scholar 

  9. A. Bendich, P. E. Brock, Intern. J. Vitam. Nutr. Res., 67 (1997) 213.

    CAS  Google Scholar 

  10. B. Fazekas, G. Molnár, T. Belgya, L. Dabolczi, A. Simonits, J. Radioanal. Nucl. Chem., 2 (1987) 271.

    Google Scholar 

  11. J. Folch, M. Lees, G. H. S. Stanley, J. Biol. Chem., 226 (1957) 497.

    CAS  Google Scholar 

  12. E. Jakob, I. Elmadfa, Intern. J. Vitam. Nutr. Res., 65 (1995) 31.

    CAS  Google Scholar 

  13. D. Majchrzak, I. Elmadfa, Ernährung/Nutrition, 25 (2001) 442.

    CAS  Google Scholar 

  14. H. Schäfer, I. Elmadfa, Ann. Nutr. Metabol., 28 (1984) 297.

    Article  Google Scholar 

  15. T. R. Shearer, D. M. Hadjimarkos, Arch. Environ. Health., 30 (1975) 230.

    CAS  Google Scholar 

  16. G. Q. Yang, P. C. Quian, L. Z. Zhu, J. H. Huang, S. J. Liv, M. B. Lu, L. Z. Gu, in: Selenium in Biology and Medicine, van Nostrand Reinhold, New York, 1987, p. 589.

  17. P. Bratter, V. E. Negretti de Bratter, J. Trace Elem. Exp. Med., 10 (1996) 163.

    CAS  Google Scholar 

  18. R. M. Parr, E. M. De Maeyer, V. G. Iyengar, A. R. Byrne, G. F. Kirkbright et al., Biol. Trace Elem. Res., 129 (1991) 51.

    Google Scholar 

  19. F. Li, E. Rossipal, K. J. Irgolic, J. Agr. Food Chem., 47 (1999) 3265.

    Article  CAS  Google Scholar 

  20. H. Robberecht, E. Roekens, M. Van Caillie-Bertrand, H. Deelstra, L. Clara, Acta Paediatr. Scand., 74 (1985) 254.

    Article  CAS  Google Scholar 

  21. M. R. L’Abbe, K. D. Trick, A. Koshy, J. Food Comp. Anal., 9 (1996) 119.

    Article  CAS  Google Scholar 

  22. Z. Mandic, M. L. Mandic, J. Grgic, D. Hasenay, Z. Grgic, Z. Lebensm. Unters. Forsch., 201 (1995) 209.

    Article  CAS  Google Scholar 

  23. J. Kumpulainen, L. Salmenpera, M. A. Siimens, P. Koivistoinen, J. Perheentupa, Am. J. Clin. Nutr., 42 (1985) 829.

    CAS  Google Scholar 

  24. N. Yamawaki, M. Yamada, T. Kan-no, T. Kojima, T. Kaneko, A. Yonekubo, J. Trace. Elem. Med. Biol., 19 (2005) 171.

    Article  CAS  Google Scholar 

  25. Y. Tamari, E. S. Kim, J. Trace Elem. Med. Biol., 13 (1999) 129.

    CAS  Google Scholar 

  26. W. Wasowicz, J. Gromadzinska, K. Szram, K. Rydzynski, J. Cieslak, Z. Pietrzak, Biol. Trace Elem. Res., 79 (2001) 221.

    Article  CAS  Google Scholar 

  27. I. Navarro-Blasco, J. L. Alvarez-Galindo, J. Trace Elem. Med. Biol., 17 (2004) 277.

    Article  CAS  Google Scholar 

  28. Y. Hojo, Sci. Total Environ., 57 (1986) 151.

    Article  CAS  Google Scholar 

  29. Y. Tamari, E. S. Kim, K. H. Lee, J. Food Sci. Nutr., 3 (1998) 260.

    CAS  Google Scholar 

  30. I. Al-Saleh, I. Al-Doush, Biometals, 10 (1997) 299.

    Article  CAS  Google Scholar 

  31. IOM (Institute of Medicine) National Academy of Sciences, Food and Nutrition Board, Panel on Dietary Antioxidants and Related Compounds, National Academy Press, Washington D.C., 2000.

    Google Scholar 

  32. D-A-CH, Deutsche Gesellschaft für Ernaehrung, Österreichische Gesellshaft für Ernaehrung, Referenzwerte für die Naehrstoffzufuhr. 1. Auflage, 2000, Frankfurt, Germany.

  33. M. F. Picciano, Biol. Neonate, 74 (1998) 84.

    Article  CAS  Google Scholar 

  34. A. Deschuytere, K. Vermeylen, H. Deelstra, Z. Lebensm. Unters. Forsch., 184 (1987) 385.

    Article  CAS  Google Scholar 

  35. M. C. Zheng, L. S. Zhou, G. F. Zhang, J. Nutr. Sci. Vitaminol., 39 (1993) 517.

    CAS  Google Scholar 

  36. C. Macias, F. J. Schweigert, Ann. Nutr. Metabol., 45 (2001) 82.

    Article  CAS  Google Scholar 

  37. E. L. Syväoja, V. Piironen, P. Varo, P. Koivistoinen, K. Salminen, Intern. J. Vitam. Nutr. Res., 55 (1985) 159.

    Google Scholar 

  38. U. Alexy, M. Kersting, W. Sichert-Hellert, F. Manz, G. Schöch, Intern. J. Vitam. Nutr. Res., 69 (1999) 285.

    Article  CAS  Google Scholar 

  39. A. S. Olafsdottir, K. H. Wagner, I. Thorsdottir, Elmadfa, Ann. Nutr. Metab., 45 (2001) 265.

    Article  CAS  Google Scholar 

  40. T. Sakurai, M. Furukawa, M. Asoh, T. Kanno, T. Kojima, A. Yonekubo, J. Nutr. Sci. Vitaminol., 51 (2005) 239.

    CAS  Google Scholar 

  41. R. M. Ortega, A. M. Lopez-Sobaler, R. M. Martinez, P. Andres, M. E. Quintas, Am. J. Clin. Nutr., 68 (1998) 662.

    CAS  Google Scholar 

  42. S. J. Gross, E. Gabriel, J. Pediatr., 106 (1985) 635.

    Article  CAS  Google Scholar 

  43. E. M. Ostrea, J. E. Balun, R. Winkler, T. Porter, Am. J. Obstet. Gynecol., 154 (1986) 1014.

    CAS  Google Scholar 

  44. D. M. Anderson, W. B. Pittard, J. Am. Diet. Assoc., 85 (1985) 715.

    CAS  Google Scholar 

  45. S. W. Souchi, W. Fachmann, H. Kraut, Food Consumption and Nutrition Tables, Medpharm Scientific Publishers, Stuttgart, 2000.

    Google Scholar 

  46. U. Alexy, M. Kersting, W. Sichert-Hellert, F. Manz, G. Shöch, Intern. J. Vitam. Nutr. Res., 69 (1999) 285.

    Article  CAS  Google Scholar 

  47. R. Brigelius-Flohé, F. J. Kelly, J. T. Salonen, J. Neuzil, J. M. Zingg, A. Azzi, Am. J. Clin. Nutr., 76 (2002) 703.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to I. Sziklai-László.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sziklai-László, I., Majchrzak, D., Elmadfa, I. et al. Selenium and vitamin E concentrations in human milk and formula milk from Hungary. J Radioanal Nucl Chem 279, 585–590 (2009). https://doi.org/10.1007/s10967-008-7311-7

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10967-008-7311-7

Keywords

Navigation