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Synthesis and biodistribution of 99mTc-peptides conjugated adenine as tumor imaging agents

  • Y. L. Zhao
  • C. L. Zhang
  • C. M. Qi
  • S. J. Feng
  • G. R. You
  • Z. L. Fu
  • F. G. Guo
  • R. F. Wang
Article

Abstract

Two peptide ligands conjugated adenine, [9-N-(tritylmercapto acetyl diglycyl aminoethyl) adenine, Tr-MAG2-Ade] and [9-N-(tritylmercapto acetyl triglycyl aminoethyl) adenine, Tr-MAG3-Ade], are synthesized and labeled with 99mTc by directly labeling method. The stability of 99mTc-MAG2-adenine and 99mTc-MAG3-adenine in vitro is measured. The uptake radios of tumor to muscle at 3h post-injection are 5.70 and 4.92, respectively. The biodistribution and scintigraphic imaging studies show that the two complexes have high localization in tumor and high contrasted tumor images can be obtained, which suggest their potential utility as tumor imaging agents. But the high radioactivity of abdomen could prevent the tumor imaging in this area.

Keywords

Adenine Radiochemical Purity Uptake Ratio White Solid 99mTc Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • Y. L. Zhao
    • 1
  • C. L. Zhang
    • 2
  • C. M. Qi
    • 1
  • S. J. Feng
    • 1
  • G. R. You
    • 1
  • Z. L. Fu
    • 2
  • F. G. Guo
    • 2
  • R. F. Wang
    • 2
  1. 1.Department of ChemistryBeijing Normal UniversityBeijingP.R. China
  2. 2.Department of Nuclear MedicinePeking University First HospitalBeijingP.R. China

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