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Synthesis and in vivo study of metallofullerene based MRI contrast agent

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Abstract

Gd@C82(OH)40 has been developed as a new generation of MRI contrast agent. But recently, it was found that Gd@C82(OH) x with a larger number of OH (x>36) would lead to cage break and hence, release of highly toxic Gd ions. We synthesized the more stable Gd@C82(OH) x with less OH-number, Gd@C82(OH)16, and studied its proton relaxivity and MRI images. The results indicate that Gd@C82(OH)16 also gives high proton relaxivity, even higher than that of (NMG)2-Gd-DTPA. The bio-distribution indicated that Gd@C82(OH)16 tends to be entrapped in the liver and kidney and remained in tissue for about 2 hours. The results suggest that the more stable metallofullerene derivative Gd@C82(OH)16 can be the potential candidate of the new MRI contrast agent.

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Authors and Affiliations

  1. School of Life Science and Technology, Beijing Institute of Technology, Beijing, 100081, P.R. China

    Jun Zhang, Kaimin Liu & Shukuan Wang

  2. Laboratory for Bio-Environmental Health Sciences of Nanoscale Materials, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, P.R. China

    Jun Zhang, Gengmei Xing & Tongxiang Ren

Authors
  1. Jun Zhang
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  2. Kaimin Liu
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  3. Gengmei Xing
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  4. Tongxiang Ren
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  5. Shukuan Wang
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Zhang, J., Liu, K., Xing, G. et al. Synthesis and in vivo study of metallofullerene based MRI contrast agent. J Radioanal Nucl Chem 272, 605–609 (2007). https://doi.org/10.1007/s10967-007-0632-0

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  • DOI: https://doi.org/10.1007/s10967-007-0632-0

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