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Journal of Radioanalytical and Nuclear Chemistry

, Volume 271, Issue 2, pp 497–501 | Cite as

A technique for the determination of ruthenium stable isotopes in urine samples

  • I. Veronese
  • M. C. Cantone
  • A. Giussani
  • A. Arogunjo
  • P. Roth
  • V. Höllriegl
  • U. Oeh
  • U. Holzwarth
  • K. Abbas
Article

Abstract

Proton activation analysis has been recently applied for the determination of stable isotopes of trace metals in blood plasma samples taken from volunteers during tracer kinetic studies. The very low values of intestinal uptake for some elements, like ruthenium, make the kinetics of the excretion crucial for interpreting the bioassay data. Therefore, a procedure has been developed to process urine samples in order to have proper targets for the activation with protons. Preliminary tests with Ru-doped samples, conducted using the MC-40 Cyclotron at JRC Ispra, has confirmed the feasibility of the method. The minimum detectable concentrations, in the current operating conditions, are 16 ng 99Ru·ml−1 and 0.5 ng 101Ru·ml−1.

Keywords

Urine Sample Ruthenium Inductively Couple Plasma Mass Spectrometry Thermal Ionization Mass Spectrometry Minimum Detectable Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Akadémiai Kiadó 2007

Authors and Affiliations

  • I. Veronese
    • 1
    • 2
  • M. C. Cantone
    • 1
    • 2
  • A. Giussani
    • 1
    • 2
  • A. Arogunjo
    • 1
  • P. Roth
    • 3
  • V. Höllriegl
    • 3
  • U. Oeh
    • 3
  • U. Holzwarth
    • 4
  • K. Abbas
    • 4
  1. 1.Dipartimento di FisicaUniversità degli Studi di MilanoItaly
  2. 2.Sezione di MilanoINFNMilanoItaly
  3. 3.Institute of Radiation ProtectionGSF, National Research Center for Environment and HealthNeuherbergGermany
  4. 4.Institute for Health and Consumer ProtectionJoint Research Centre of the European CommissionIspra (Va)Italy

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