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Optimization of the production of [61Cu]Diacetyl-bis(N4-methylthiosemicarbazone) for PET studies

  • A. R. Jalilian
  • M. Sabet
  • P. Rowshanfarzad
  • M. Kamali-dehghan
  • M. Akhlaghi
  • M. Mirzaii
Article

Summary

Copper-61 produced via the natZn(p,x)61Cu nuclear reaction was used for the preparation of [61Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([61Cu]ATSM) (4) using a house-made ATSM ligand. After a proton irradiation of an electroplated zinc layer by 22 MeV protons at 180 mA for 3.2 hours, 61Cu was recovered by two-step chromatography using a cation and an anion exchange column. About 222 GBq (6.00 Ci) of 61Cu2+ was obtained with a radiochemical separation yield of more than 95% and a radionuclidic purity of better than 99%. Colorimetric methods showed that traces of chemical impurities in the product were below the accepted limits. The [61Cu]ATSM production was optimized for reaction conditions (buffer concentration and temperature) with a radiochemical yield of higher than 80%, radiochemical purity of better than 98% and a specific activity of about 246 Ci/mmol. The produced [61Cu]ATSM is a PET radiotracer for hypoxia imaging with an intermediate half life and a satisfactory quality, suitable for future PET studies.

Keywords

Radiochemical Purity Radionuclidic Purity Zinc Isotope Proton Beam Energy Radio Thin Layer Chromatography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Akadémiai Kiadó 2006

Authors and Affiliations

  • A. R. Jalilian
    • 1
  • M. Sabet
    • 2
  • P. Rowshanfarzad
    • 3
  • M. Kamali-dehghan
    • 4
  • M. Akhlaghi
    • 5
  • M. Mirzaii
    • 6
  1. 1.Cyclotron and Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine, Atomic Energy Organization of Iran
  2. 2.SSDL and Health Physics Department, Nuclear Research Center for Agriculture and Medicine, Atomic Energy Organization of Iran
  3. 3.Cyclotron and Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine, Atomic Energy Organization of Iran
  4. 4.Cyclotron and Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine, Atomic Energy Organization of Iran
  5. 5.Cyclotron and Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine, Atomic Energy Organization of Iran
  6. 6.Cyclotron and Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine, Atomic Energy Organization of Iran

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