Journal of Radioanalytical and Nuclear Chemistry

, Volume 265, Issue 3, pp 505–506 | Cite as

A facile synthesis of 4,6-dimethoxy-[2-14C]-2-methylsulphonylpyrimidine

  • K. M. Mathew
  • S. Ravi
  • D. Padmanabhan


4,6-dimethoxy-2-methylsulphonylpyrimidine is a key intermediate for the synthesis of pyrithiobac-sodium, a selective herbicide for cotton plant. 14C labeled pyrithiobac-sodium is required for studying the translocation and metabolism in cotton plants. It was prepared by oxidation of 4,6-dimethoxy-[2-14C]-2-methylmercaptopyrimidine with H5IO6/CrO3 in ethyl acetate at room temperature to give 4,6-dimethoxy-[2-14C]-2-methylsulphonylpyrimidine in high yields.


Oxidation Acetate Physical Chemistry Ethyl Inorganic Chemistry 
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Copyright information

© Springer-Verlag/Akadémiai Kiadó 2005

Authors and Affiliations

  • K. M. Mathew
    • 1
  • S. Ravi
    • 2
  • D. Padmanabhan
    • 3
  1. 1./ILCJ, Board of Radiation and Isotope Technology
  2. 2./ILCJ, Board of Radiation and Isotope Technology
  3. 3./ILCJ, Board of Radiation and Isotope Technology

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