Rapid separation of fresh fission products
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A novel radiochemical separation for <Superscript>48</Superscript>V radiotracer in no-carrier-added (NCA) form, via proton irradiation on Ti targets of natural isotopic composition has been developed. Metallic Ti targets irradiated with 21 MeV proton beam energy was submitted to a selective radiochemical separation consisting of an alkaline fusion-precipitation step, followed by column Chelex-100 chromatographic purification. Very high specific activity <Superscript>48</Superscript>V, at levels of hundreds MBq<Superscript> .</Superscript>µg<Superscript>-1</Superscript> was prepared. Chemical analysis of radiotracer was carried out by ET-AAS and INAA. The decontamination factor from Ti target was 5<Superscript> .</Superscript> 10<Superscript>5</Superscript>, with an overall radiochemical yield for <Superscript>48</Superscript>V larger than 90%. The NCA <Superscript>48</Superscript>V has used for labeling a range of chemical forms of V(III, IV, V) and applied in the study of metabolic behavior of different chemical forms in in-vivo and in-vitro experiments on rats and cell cultures.
KeywordsINAA Proton Beam Fission Product High Specific Activity Radiochemical Yield
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