Self-assembly nucleic acid-based biopolymers: learn from the nature
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This review highlights the recent developments in nucleic acid-based based materials for biomedical applications and functional devices. DNA and RNA are anionic macromolecules composing sugar-phosphate backbone, which usually structure as rod-like double helix with base pair stacking. Electrostatic interactions are the main components in the complex formed between anionic nucleic acid and cationic molecule. These nucleic acid-based biopolymers have significant potential as functional materials for drug delivery, biosensors, and a scaffold for many biodegradable materials.
KeywordsDNA RNA Self-assembly Electrostatic interaction Supramolecular material Functional material
This work is supported by Kasetsart University Research and Development Institute (KURDI), Kasetsart University, Thailand. The authors would like to gratefully acknowledge Professor Matthew Tirrell from University of Chicago for all the supports.
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