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pH-responsive magnetic nanocomposites based on poly(2-succinyloxyethyl methacrylate-co-methylmethacrylate) for anticancer doxorubicin delivery applications

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Abstract

A novel pH-responsive Fe3O4/poly(2-succinyloxyethylmethacrylate-co-methylmethacrylate) (poly(SEMA-co-MMA)) nanocomposite was designed for anticancer drug delivery applications. For this propose, poly(2-hydroxyethyl methacrylate-co-methylmethacrylate) (poly(HEMA-co-MMA)) was synthesized via reversible addition-fragmentation transfer (RAFT) method. Then, poly(SEMA-co-MMA) was prepared by the esterification of poly(HEMA-co-MMA) copolymer through the reaction with an excess amount of succinic anhydride. The synthesized copolymers with acidic functional groups were adsorbed onto the surface of Fe3O4 nanoparticles and Fe3O4/poly(SEMA-co-MMA) nanocomposite was developed. The pH-sensitivity of Fe3O4/poly(SEMA-co-MMA) nanocomposite was confirmed via dynamic light scattering (DLS) measurements. The Doxorubicin (DOX) encapsulation efficiency was 92.6%. The release rates at pHs of 5.4 and 4 (37 °C) reached 55.7 and 62.4 wt%, respectively, and at pH = 7.4, it possessed a minimum amount around 38.3 wt% after 15 days. The synthesized nanocomposite may be find the drug delivery applications, in part thanks to their smart physicochemical properties.

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Acknowledgements

We express our gratitude to the Payame Noor University for supporting this project.

Funding

This study was not funded.

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Authors and Affiliations

  1. Department of Chemistry, Payame Noor University, Tehran, Iran

    Aliyeh Ghamkhari, Nahid Poorgholy & Bakhshali Massoumi

  2. Chemical Engineering Department, Faculty of Engineering, Azarbaijan Shahid Madani University, Tabriz, Iran

    Samira Agbolaghi

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  1. Aliyeh Ghamkhari
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  2. Samira Agbolaghi
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  3. Nahid Poorgholy
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  4. Bakhshali Massoumi
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Correspondence to Bakhshali Massoumi.

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Ghamkhari, A., Agbolaghi, S., Poorgholy, N. et al. pH-responsive magnetic nanocomposites based on poly(2-succinyloxyethyl methacrylate-co-methylmethacrylate) for anticancer doxorubicin delivery applications. J Polym Res 25, 37 (2018). https://doi.org/10.1007/s10965-017-1431-0

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  • DOI: https://doi.org/10.1007/s10965-017-1431-0

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