pH-responsive magnetic nanocomposites based on poly(2-succinyloxyethyl methacrylate-co-methylmethacrylate) for anticancer doxorubicin delivery applications
- 126 Downloads
A novel pH-responsive Fe3O4/poly(2-succinyloxyethylmethacrylate-co-methylmethacrylate) (poly(SEMA-co-MMA)) nanocomposite was designed for anticancer drug delivery applications. For this propose, poly(2-hydroxyethyl methacrylate-co-methylmethacrylate) (poly(HEMA-co-MMA)) was synthesized via reversible addition-fragmentation transfer (RAFT) method. Then, poly(SEMA-co-MMA) was prepared by the esterification of poly(HEMA-co-MMA) copolymer through the reaction with an excess amount of succinic anhydride. The synthesized copolymers with acidic functional groups were adsorbed onto the surface of Fe3O4 nanoparticles and Fe3O4/poly(SEMA-co-MMA) nanocomposite was developed. The pH-sensitivity of Fe3O4/poly(SEMA-co-MMA) nanocomposite was confirmed via dynamic light scattering (DLS) measurements. The Doxorubicin (DOX) encapsulation efficiency was 92.6%. The release rates at pHs of 5.4 and 4 (37 °C) reached 55.7 and 62.4 wt%, respectively, and at pH = 7.4, it possessed a minimum amount around 38.3 wt% after 15 days. The synthesized nanocomposite may be find the drug delivery applications, in part thanks to their smart physicochemical properties.
KeywordsRAFT Magnetic nanocomposite Drug delivery pH-responsive
We express our gratitude to the Payame Noor University for supporting this project.
This study was not funded.
Compliance with ethical standards
Conflict of Interest
The authors declare that they have no conflict of interest.
- 18.Delaittre G, Save M, Gaborieau M, Castignolles P, Rieger J, Charleux B (2012) Synthesis by nitroxide-mediated aqueous dispersion polymerization, characterization, and physical core-crosslinking of pH- and thermoresponsive dynamic diblock copolymer micelles. Polym Chem 3:1526–1538CrossRefGoogle Scholar
- 21.Davaran S, Ghamkhari A, Alizadeh E, Massoumi B, Jaymand M (2017) Novel dual stimuli-responsive ABC triblock copolymer: RAFT synthesis, Schizophrenic” micellization and its performance as an anticancer drug delivery nanosystem J Colloid Interface Sci 488:282–293Google Scholar
- 28.Massoumi B, Ghamkhari A, Agbolaghi S (2017) Dual stimuli-responsive poly(succinyloxyethylmethacrylate-b-N-Isopropylacrylamide) block copolymers as nano-carriers and respective application in Doxorubicin delivery. Int J Polym Mater. https://doi.org/10.1080/00914037.2017.1300901