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Journal of Polymer Research

, 25:37 | Cite as

pH-responsive magnetic nanocomposites based on poly(2-succinyloxyethyl methacrylate-co-methylmethacrylate) for anticancer doxorubicin delivery applications

  • Aliyeh Ghamkhari
  • Samira Agbolaghi
  • Nahid Poorgholy
  • Bakhshali Massoumi
ORIGINAL PAPER

Abstract

A novel pH-responsive Fe3O4/poly(2-succinyloxyethylmethacrylate-co-methylmethacrylate) (poly(SEMA-co-MMA)) nanocomposite was designed for anticancer drug delivery applications. For this propose, poly(2-hydroxyethyl methacrylate-co-methylmethacrylate) (poly(HEMA-co-MMA)) was synthesized via reversible addition-fragmentation transfer (RAFT) method. Then, poly(SEMA-co-MMA) was prepared by the esterification of poly(HEMA-co-MMA) copolymer through the reaction with an excess amount of succinic anhydride. The synthesized copolymers with acidic functional groups were adsorbed onto the surface of Fe3O4 nanoparticles and Fe3O4/poly(SEMA-co-MMA) nanocomposite was developed. The pH-sensitivity of Fe3O4/poly(SEMA-co-MMA) nanocomposite was confirmed via dynamic light scattering (DLS) measurements. The Doxorubicin (DOX) encapsulation efficiency was 92.6%. The release rates at pHs of 5.4 and 4 (37 °C) reached 55.7 and 62.4 wt%, respectively, and at pH = 7.4, it possessed a minimum amount around 38.3 wt% after 15 days. The synthesized nanocomposite may be find the drug delivery applications, in part thanks to their smart physicochemical properties.

Keywords

RAFT Magnetic nanocomposite Drug delivery pH-responsive 

Notes

Acknowledgements

We express our gratitude to the Payame Noor University for supporting this project.

Funding

This study was not funded.

Compliance with ethical standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Aliyeh Ghamkhari
    • 1
  • Samira Agbolaghi
    • 2
  • Nahid Poorgholy
    • 1
  • Bakhshali Massoumi
    • 1
  1. 1.Department of ChemistryPayame Noor UniversityTehranIran
  2. 2.Chemical Engineering Department, Faculty of EngineeringAzarbaijan Shahid Madani UniversityTabrizIran

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