Preparation and characterization of novel thermosensitive magnetic molecularly imprinted polymers for selective recognition of norfloxacin

  • Weihong Huang
  • Yu Kong
  • Wenming Yang
  • Xiaoni Ni
  • Ningwei Wang
  • Yi Lu
  • Wanzhen Xu


Novel norfloxacin (NOR) thermosensitive magnetic molecularly imprinted polymers (T-MMIPs) were prepared with functional monomer methacrylic acid (MAA), temperature-response monomer N-isopropylacrylamide (NIPAM) and cross-linking agent N,N′-methylenebisacrylamide (MBA) by the surface imprinting technique. The silica layer and imprinted polymers layer coated on the surface of Fe3O4 nanoparticles, forming double-shell structure. The morphology and composition of the thermosensitive magnetic molecularly imprinted polymers were investigated by transmission electronmicroscope (TEM), Fourier transform infrared spectrometry (FT-IR), thermogravimetic (TGA), vibrating sample magnetometer (VSM), powder X-ray diffraction (XRD) and nitrogen adsorption analysis. The phase behavior and thermosensitivity of T-MMIPs were studied by swelling experiments and adsorption tests at different temperatures. And the adsorption performance of T-MMIPs at 35 °C were evaluated by adsorption experiments, including kinetic, isotherm and selectivity tests. The maximum capacity of T-MMIPs at 35 °C was 52.85 mg g−1. In selective recognition tests, the T-MMIPs showed the highest selectivity for NOR among four components while the T-MNIPs showed similarly adsorption for all components. The prepared T-MMIPs have great potential in the detection and separation of norfloxacin due to the good temperature response, adsorption capacity, selectivity and reusability.


Molecularly imprinted polymers Norfloxacin Thermosensitive Selective 



This work was supported by the Jiangsu Natural Science Foundation of China (contract grant numbers BK20141287, BK20151323 and BK20151337), Postdoctoral Science Foundation of China (contract grant numbers 2014 M560405 and 2015 T80515), Postdoctoral Science Foundation of Jiangsu Province (contract grant number 1401012 A), Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Social Development Fund of Jiangsu Province (contract grant number SH2014020).


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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Weihong Huang
    • 1
  • Yu Kong
    • 1
  • Wenming Yang
    • 2
  • Xiaoni Ni
    • 3
  • Ningwei Wang
    • 4
  • Yi Lu
    • 4
  • Wanzhen Xu
    • 1
  1. 1.School of Environment and Safety EngineeringJiangsu UniversityZhenjiangChina
  2. 2.School of Materials Science and EngineeringJiangsu UniversityZhenjiangChina
  3. 3.Zhenjiang Institute for Drug Control of Jiangsu ProvinceZhenjiangChina
  4. 4.Zhenjiang Entry-Exit Inspection Quarantine BureauZhenjiangPeople’s Republic of China

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