Journal of Polymer Research

, 22:170 | Cite as

Tunable thermo-responsive supramolecular hydrogel: design, characterization, and drug release

  • Mi Zhou
  • Xiaofeng Ye
  • Kaiyue Liu
  • Jingying Hu
  • Xin Qian
Original Paper


During the past decade, a series of thermo-responsive hydrogels based on poly(N-isopropylacrylamide) (PNIPAM) were prepared for drug delivery. However, the release performance of those hydrogels was limited because the LCST (lower critical solution temperature) of PNIPAM (about 32 °C) is slightly lower than human body temperature, and the drug loading is complicated. To develop a new drug delivery matrix with the suitable responsive interval, a novel, temperature-sensitive copolymer with two monomers, N-isopropylacrylamide and methylacrylic polyethylene glycol monomethyl ether ester (MPEGMA) [poly(NIPAM-co-MPEGMA)], was synthesized by free radical polymerization. Then, the supramolecular hydrogels with tunable response temperature, whose structures were confirmed by X-ray diffraction (XRD), were fabricated via inclusion complexation with α-cyclodextrin (α-CD) and the copolymers in aqueous solution. The rheology results indicated that response interval could be modulated by controlling the contents of PNIPAM in the copolymers. Compared to the normal PNIPAM ge1, the succinct method of gel preparation streamlined the process of loading and made the drug loading capacity controllable. The release time was proved to be prolonged by the release kinetics of 5-fluoroucrail (5-Fu), which showed feasibility as a drug delivery.


Thermo-responsive Supramolecular hydrogel Drug delivery Self-assembly 



This work is supported by National Natural Science Foundation of China (No. 21004053) and the Opening Foundation of Zhejiang Provincial Top Key Discipline (No. 20121109).

Supplementary material

10965_2015_804_MOESM1_ESM.doc (1.8 mb)
ESM 1 (DOC 1851 kb)


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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.College of Materials Science and EngineeringZhejiang University of TechnologyHangzhouChina

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