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Synthesis of novel amphiphilic graft copolymers composed of poly(ethylene oxide) as backbone and polylactide as side chains

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Abstract

A well-defined amphiphilic comb-like copolymer of poly(ethylene oxide)(PEO) as main chain and polylactide (PLA) as side chain was successfully prepared via a combination of anionic polymerization and coordination-insertion ring-opening polymerization. The anionic copolymerization of ethylene oxide (EO) and ethoxyethyl glycidyl ether (EEGE) was carried out using potassium 2-(2-methoxyethoxy)ethoxide as initiator, and then ethoxyethyl groups of EEGE units of the copolymers obtained were removed by hydrolysis. Two copolymers of methoxypoly(ethylene oxide-co-glycidol) [mpoly(EO-co-Gly)] were formed with multiple hydroxyl sites (the molar ratio values of Gly to EO in copolymers: 1/10.6 and 1/5.2; Mn: 10,100 and 5,020 respectively), and them were used further to initiate the ring-opening polymerization of lactide in the presence of stannous octoate, and a well-defined comb-like copolymer of PEO as main chain and PLA as side chain was obtained. The intermediate and final products of PEO-g-PLA were characterized by GPC and NMR in detail.

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References

  1. Wu YD, Liu CB, Zhao XY, Xiang JN (2008) J Polym Res 15:181

    Article  Google Scholar 

  2. Lin JJ, Shao SM, Tseng FP, Cheng FC (2000) J Polym Res 1:21

    Article  Google Scholar 

  3. Stiriba SE, Kautz H, Frey H (2002) J Am Chem Soc 124:9698

    Article  CAS  Google Scholar 

  4. He LH, Huang J, Chen YM, Xu XJ, Liu LP (2005) Macromolecules 38:3845

    Article  CAS  Google Scholar 

  5. Zhang MF, Drechsler M, Muller AHE (2004) Chem Mater 16:537

    Article  CAS  Google Scholar 

  6. Ramin DR, Li S, Schmidt M (2002) Macromolecules 35:4282

    Article  Google Scholar 

  7. Zhang MF, Muller AHE (2005) J Polym Sci Part A Polym Chem 43:3461

    Article  CAS  Google Scholar 

  8. Langer R (1990) Science 249:1527

    Article  CAS  Google Scholar 

  9. Barrera DH, Zylstra E, Lansbury PT, Langer R (1993) J Am Chem Soc 115:11010

    Article  CAS  Google Scholar 

  10. Herold CB, Keil K, Bruns DE (1989) Biochem Pharmacol 38:73

    Article  CAS  Google Scholar 

  11. Cohn D, Hotovely SA (2005) Polymer 46:2068

    Article  CAS  Google Scholar 

  12. Lee SY, Chin IJ, Jung JS (1999) Eur Polym J 35:2147

    Article  CAS  Google Scholar 

  13. Pan J, Venkatraman SS, Feng M, Freddy BYC, Huat GL (2005) J Control Rel 110:20

    Article  Google Scholar 

  14. Jeong B, Choi YK, Bae YH, Zentner G, Kim SM (1999) J Control Release 62:109

    Article  CAS  Google Scholar 

  15. Zhou SB, Deng XM, Yang H (2003) Biomaterials 24:3563

    Article  CAS  Google Scholar 

  16. Sosnik A, Cohn D (2003) Polymer 44:7033

    Article  CAS  Google Scholar 

  17. Li ZY, Li PP, Huang JL (2006) J Polym Sci Part A Polym Chem 44:4361

    Article  CAS  Google Scholar 

  18. Wei J, Huang JL (2005) Macromolecules 38:1107

    Article  CAS  Google Scholar 

  19. Taton D, Borgne A, Sepulchre M, Soassky N (1994) Macromol Chem Phys 195:139

    Article  CAS  Google Scholar 

  20. Allgaier J, Willbold S, Chang TH (2007) Macromolecules 40:518

    Article  CAS  Google Scholar 

  21. Storey RF, Sherman JW (2002) Macromolecules 35:1504

    Article  CAS  Google Scholar 

Download references

Acknowledgement

The finial support for this work, provided by the Henan Science Foundation of the People’s Republic of China for Outstanding Youth (74100510025) and the Natural Science Foundation of Education Department of Henan Province (2009A430018), is highly appreciated.

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Authors and Affiliations

  1. Department of Digestive Medicine, the First Affiliated Hospital, Zhengzhou University, Jianshe Road, Zhengzhou, 450052, People’s Republic of China

    Qunying Wang

  2. School of Materials Science and Engineering, Zhengzhou University, Daxue Road, Zhengzhou, 450052, People’s Republic of China

    Yudong Wang

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  1. Qunying Wang
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  2. Yudong Wang
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Correspondence to Yudong Wang.

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Wang, Q., Wang, Y. Synthesis of novel amphiphilic graft copolymers composed of poly(ethylene oxide) as backbone and polylactide as side chains. J Polym Res 18, 385–391 (2011). https://doi.org/10.1007/s10965-010-9428-y

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  • DOI: https://doi.org/10.1007/s10965-010-9428-y

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