Thermo-sensitive hydrogels formed from the photocrosslinkable polypseudorotaxanes consisting of β-cyclodextrin and Pluronic F68/PCL macromer
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To create thermo-sensitive supramolecular hydrogels with high mechanical strength, viscous gel precursors were first formed via block-selected inclusion complexation between β-cyclodextrin (β-CD) and Pluronic F68/poly(ε-caprolactone) block copolymer terminated with acryloyl groups in aqueous media, and subsequently in situ photocrosslinking was employed in the presence of a photoinitiator. The supramolecular assembly in photocrosslinked hydrogels was revealed by wide-angle X-ray diffraction (WXRD) and thermogravimetric analysis (TGA). The rheological studies demonstrated that in situ photocrosslinking could greatly improve the mechanical strength of the gellike precursors. The swelling measurements showed that as-obtained hydrogel displayed a thermo-responsive property. The temperature dependence of the hydrogels decreased with the increase of the β-CD amounts introduced. The resultant hydrogels have the potential to use as carriers for drug delivery and tissue engineering scaffolds.
KeywordsSupramolecular hydrogel Inclusion complexation Photocrosslinking Mechanical strength Thermo-responsiveness
This work was supported by Grants from the Major State Basic Research Development Program of China (973 Program) (No. 2009CB526402), the Nature Science Foundation of Hubei Province (No. 2007ABB033) and WUSE Research Fund (No. 2008Z01).
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