Journal of Solution Chemistry

, Volume 44, Issue 8, pp 1723–1748 | Cite as

Glass Formation in Binary Solutions of Acetaminophen with Guaifenesin and Mephenesin

  • Manoj K. Saini
  • S. S. N. Murthy


Dielectric behavior and glass formation in supercooled liquid guaifenesin (GFN) and its binary liquids with acetaminophen (ACT), and of ACT with mephenesin (MP), are reported using dielectric spectroscopy (10−3 Hz–2 MHz) and differential scanning calorimetry down to liquid nitrogen temperature. Solid–liquid phase equilibria of ACT + GFN and ACT + MP exhibit a simple eutectic of complete miscibility in the liquid state with eutectic points at 344.6 (±1) K and 337.5 (±1.4) K, respectively, and separate into two crystalline components in the solid state. The glass transition temperature (T g) measured for quenched binary liquids obeys a mixture rule. The primary relaxation process (α-process), can be well described by the Havriliak–Negami equation. A secondary relaxation process (β-process), found below T g, is Arrhenius in its temperature dependence, but may not be of inter-molecular or Johari–Goldstein (JG) type in nature. The “fragility” of the samples is discussed in the context of a coupling model. The supercooled liquid samples and binary liquids studied here are found to be “very fragile” in nature.


Binary mixture of pharmaceuticals Dielectric spectroscopy Differential scanning calorimetry (DSC) Glass transition Guaifenesin 



The authors like to thank Dept. of Science & Technology & UGC, Govt. of India for the financial support. One of the authors (Manoj K. Saini) acknowledges the Research fellowship from UGC, India.

Supplementary material

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Supplementary material 1 (PDF 285 kb)


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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.School of Physical SciencesJawaharlal Nehru UniversityNew DelhiIndia

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