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Glass Formation in Binary Solutions of Acetaminophen with Guaifenesin and Mephenesin

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Abstract

Dielectric behavior and glass formation in supercooled liquid guaifenesin (GFN) and its binary liquids with acetaminophen (ACT), and of ACT with mephenesin (MP), are reported using dielectric spectroscopy (10−3 Hz–2 MHz) and differential scanning calorimetry down to liquid nitrogen temperature. Solid–liquid phase equilibria of ACT + GFN and ACT + MP exhibit a simple eutectic of complete miscibility in the liquid state with eutectic points at 344.6 (±1) K and 337.5 (±1.4) K, respectively, and separate into two crystalline components in the solid state. The glass transition temperature (T g) measured for quenched binary liquids obeys a mixture rule. The primary relaxation process (α-process), can be well described by the Havriliak–Negami equation. A secondary relaxation process (β-process), found below T g, is Arrhenius in its temperature dependence, but may not be of inter-molecular or Johari–Goldstein (JG) type in nature. The “fragility” of the samples is discussed in the context of a coupling model. The supercooled liquid samples and binary liquids studied here are found to be “very fragile” in nature.

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Acknowledgments

The authors like to thank Dept. of Science & Technology & UGC, Govt. of India for the financial support. One of the authors (Manoj K. Saini) acknowledges the Research fellowship from UGC, India.

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  1. School of Physical Sciences, Jawaharlal Nehru University, New Delhi, 110067, India

    Manoj K. Saini & S. S. N. Murthy

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Correspondence to S. S. N. Murthy.

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Saini, M.K., Murthy, S.S.N. Glass Formation in Binary Solutions of Acetaminophen with Guaifenesin and Mephenesin. J Solution Chem 44, 1723–1748 (2015). https://doi.org/10.1007/s10953-015-0364-7

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