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Preferential Solvation of Ketoprofen in Some Co-solvent Binary Mixtures

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Abstract

The preferential solvation parameters of ketoprofen (KTP) in ethanol (EtOH) + water and propylene glycol (PG) + water binary solvent mixtures were obtained from their thermodynamic properties by means of the inverse Kirkwood–Buff integrals (IKBI) and quasi-lattice quasi-chemical methods. According to the IKBI method, it is found that KTP is very sensitive to specific solvation effects, so the preferential solvation parameter by co-solvents, δx 1,3, is negative in the water-rich mixtures of both binary systems but positive in the other compositions at temperatures of 293.15, 303.15 and 313.15 K. From this it can be assumed that, in water-rich mixtures, hydrophobic hydration around the aromatic rings and the methyl group, present in the drug, plays a relevant role in the solvation. The bigger amount of drug solvation by the co-solvent in mixtures of similar solvent proportions and in co-solvent-rich mixtures could be due mainly to polarity effects. Moreover, in these mixtures the solute will be acting as a Lewis acid with the co-solvent molecules, because they are more basic than water.

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Authors and Affiliations

  1. Grupo de Investigaciones Farmacéutico Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, A.A. 14490, Bogotá D.C., Colombia

    Zaira J. Cárdenas, Daniel M. Jiménez & Fleming Martínez

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  1. Zaira J. Cárdenas
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  2. Daniel M. Jiménez
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  3. Fleming Martínez
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Correspondence to Fleming Martínez.

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Cárdenas, Z.J., Jiménez, D.M. & Martínez, F. Preferential Solvation of Ketoprofen in Some Co-solvent Binary Mixtures. J Solution Chem 43, 1904–1915 (2014). https://doi.org/10.1007/s10953-014-0255-3

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