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Journal of Solution Chemistry

, Volume 43, Issue 11, pp 1904–1915 | Cite as

Preferential Solvation of Ketoprofen in Some Co-solvent Binary Mixtures

  • Zaira J. Cárdenas
  • Daniel M. Jiménez
  • Fleming Martínez
Article

Abstract

The preferential solvation parameters of ketoprofen (KTP) in ethanol (EtOH) + water and propylene glycol (PG) + water binary solvent mixtures were obtained from their thermodynamic properties by means of the inverse Kirkwood–Buff integrals (IKBI) and quasi-lattice quasi-chemical methods. According to the IKBI method, it is found that KTP is very sensitive to specific solvation effects, so the preferential solvation parameter by co-solvents, δx 1,3, is negative in the water-rich mixtures of both binary systems but positive in the other compositions at temperatures of 293.15, 303.15 and 313.15 K. From this it can be assumed that, in water-rich mixtures, hydrophobic hydration around the aromatic rings and the methyl group, present in the drug, plays a relevant role in the solvation. The bigger amount of drug solvation by the co-solvent in mixtures of similar solvent proportions and in co-solvent-rich mixtures could be due mainly to polarity effects. Moreover, in these mixtures the solute will be acting as a Lewis acid with the co-solvent molecules, because they are more basic than water.

Keywords

Ketoprofen Ethanol Propylene glycol Preferential solvation IKBI QLQC 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Zaira J. Cárdenas
    • 1
  • Daniel M. Jiménez
    • 1
  • Fleming Martínez
    • 1
  1. 1.Grupo de Investigaciones Farmacéutico Fisicoquímicas, Departamento de Farmacia, Facultad de CienciasUniversidad Nacional de ColombiaBogotá D.C.Colombia

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