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Partition Coefficients and Solubilities of Compounds in the Water–Ethanol Solvent System

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Abstract

A new method for the prediction of solubility in the water–ethanol system has been devised. The method is based on the construction of equations for the prediction of partition coefficients from water to water–ethanol mixtures, based on the Abraham descriptors for compounds. Once partition coefficients have been predicted for a particular compound, only an experimental value for the solubility in ethanol is required for the prediction of solubilities in water–ethanol mixtures. Results of predictions are comparable to the Jouyban-Acree model that requires experimental solubilities in both water and ethanol.

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Authors and Affiliations

  1. Department of Chemistry, University College London, 20 Gordon St, London, WC1H 0AJ, UK

    Michael H. Abraham

  2. Department of Chemistry, University of North Texas, 1155 Union Circle Drive #305070, Denton, TX, 76203-5017, USA

    William E. Acree Jr.

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  1. Michael H. Abraham
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  2. William E. Acree Jr.
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Correspondence to Michael H. Abraham.

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Abraham, M.H., Acree, W.E. Partition Coefficients and Solubilities of Compounds in the Water–Ethanol Solvent System. J Solution Chem 40, 1279–1290 (2011). https://doi.org/10.1007/s10953-011-9719-x

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