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Journal of Solution Chemistry

, Volume 40, Issue 7, pp 1279–1290 | Cite as

Partition Coefficients and Solubilities of Compounds in the Water–Ethanol Solvent System

  • Michael H. Abraham
  • William E. AcreeJr.
Article

Abstract

A new method for the prediction of solubility in the water–ethanol system has been devised. The method is based on the construction of equations for the prediction of partition coefficients from water to water–ethanol mixtures, based on the Abraham descriptors for compounds. Once partition coefficients have been predicted for a particular compound, only an experimental value for the solubility in ethanol is required for the prediction of solubilities in water–ethanol mixtures. Results of predictions are comparable to the Jouyban-Acree model that requires experimental solubilities in both water and ethanol.

Keywords

Water–ethanol Solubility Partition coefficients Abraham descriptors Linear free energy relationship Multiple linear regression 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of ChemistryUniversity College LondonLondonUK
  2. 2.Department of ChemistryUniversity of North TexasDentonUSA

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