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Interaction of 1,4-Dihydroxy–9,10-Anthraquinone with Calf Thymus DNA: A Comparison with Anthracycline Anticancer Drugs

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Abstract

The anthracycline drugs adriamycin and daunorubicin, efficient in the treatment of various human cancers, form strong intercalation complexes with DNA. The therapeutic efficacy and toxicity of such anticancer drugs are governed by biochemical reactions of the core dihydroxy-9,10-anthraquinone unit. The high cost and toxic side effects of anthracycline drugs limit their use in cancer therapy. For a few decades, efforts have been made to find cheap, less toxic yet efficient analogues of anthracyclines. This work on 1,4-dihydroxy-9,10-anthraquinone (QH2), a simple analogue of the anthracyclines, was carried out to compare its biochemical properties with anthracyclines. UV-Vis and fluorescence spectroscopic methods were used to analyze interaction of the compound with calf thymus DNA. The data were used to evaluate the binding constant and site size.

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Abbreviations

QH2 :

1,4-dihydroxy-9,10-anthraquinone

ctDNA:

calf thymus DNA

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Author notes

  1. Partha Sarathi Guin

    Present address: Department of Chemistry, Shibpur Dinobundhoo Institution (College), 412/1 G.T. Road (South), Howrah, 711102, W.B., India

Authors and Affiliations

  1. Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF-Bidhannagar, Kolkata, 700064, India

    Partha Sarathi Guin & Parikshit Chandra Mandal

  2. Department of Chemistry, Jadavpur University, Raja S.C. Mullick Road, Kolkata, 700032, India

    Partha Sarathi Guin & Saurabh Das

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  1. Partha Sarathi Guin
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  2. Saurabh Das
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Correspondence to Parikshit Chandra Mandal.

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Guin, P.S., Das, S. & Mandal, P.C. Interaction of 1,4-Dihydroxy–9,10-Anthraquinone with Calf Thymus DNA: A Comparison with Anthracycline Anticancer Drugs. J Solution Chem 40, 492–501 (2011). https://doi.org/10.1007/s10953-011-9654-x

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