Advertisement

Journal of Structural Chemistry

, Volume 47, Issue 1, pp 170–177 | Cite as

Conformational changes of DNA molecules in interactions with bioactive compounds. II. DNA complexes with coordination compounds of cobalt and ruthenium

  • N. A. Kas’yanenko
  • D. A. Afanasieva
Article

Abstract

A comparative analysis is made of the character of conformational changes of the DNA molecule in its interaction with coordination compounds of cobalt and ruthenium with different ligand sets in the coordination sphere of the ion. It is shown that during complexation global conformational changes of DNA (e.g., the reduction of its volume) practically do not depend on the location and on the binding mode of the complex ion, but are primarily determined by its charge, whereas local conformational changes of the macromolecule are very sensitive to the type of the complex being formed, as indicated by the change of spectral properties of DNA. An assessment of sizes of the particles that are formed as a result of DNA condensation due to its binding with trivalent ions of cobalt and ruthenium was performed with the use of dynamic light scattering.

Keywords

DNA complexes with ruthenium and cobalt coordinate compounds 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    D. Frasca, J. Ciampa, J. Emerson, R. S. Umans, and M. Clarke, J. Metal-Based Drugs., 3, 197–209 (1996).Google Scholar
  2. 2.
    K. A. Marx, R. Kruger, and M. Clarke, J. Mol. Cell. Biochem., 86, 155–162 (1989).Google Scholar
  3. 3.
    G. Sava, S. Pacor, F. Bregant, V. Ceschia, and G. Metroni, Anticancer Drugs., 1(2), 99–108 (1990).Google Scholar
  4. 4.
    P. Som, Z. H. Oster, K. Matsui, et al., Eur. J. Nucl. Med., 8, 491 (1983).CrossRefGoogle Scholar
  5. 5.
    A. D. Kelman, M. J. Clarke, S. D. Edmonds, and H. J. Peresie, J. Clin. Hematol. Oncol., 7, 274 (1977).Google Scholar
  6. 6.
    N. A. Kas’yanenko, E. E. F. Aia, A. A. Bogdanov, et al., Molekulyar. Bio., 36, 1 (2003).Google Scholar
  7. 7.
    N. A. Kas’yanenko, E. V. Frisman, S. V. Valueva, et al., ibid., 29, 345 (1995).Google Scholar
  8. 8.
    J. Reedijk, PNAS, 100, 3611 (2003).CrossRefGoogle Scholar
  9. 9.
    C. Kumar, J. Barton, and N. Turro, J. Am. Chem. Soc., 107, 5518–5523 (1985).CrossRefGoogle Scholar
  10. 10.
    G.-Y. Bai, K.-Z. Wang, Z.-M. Duan, and L.-H. Gao, J. Inorg. Biochem., 98, 1017–1022 (2004).CrossRefGoogle Scholar
  11. 11.
    L. Ling, Z. He, G. Song, et al., Anal. Chim. Acta., 436, 207–214 (2001).CrossRefGoogle Scholar
  12. 12.
    L. C. Gosule and J. A. Schellman, Nature, 259, 333 (1976).CrossRefGoogle Scholar
  13. 13.
    J. Widom and R. L. Baldwin, J. Mol. Bio., 144, 431 (1980).CrossRefGoogle Scholar
  14. 14.
    V. A. Bloomfield, Biopolimers, 31, 1471 (1991).CrossRefGoogle Scholar
  15. 15.
    T. J. Thomas and R. P. Messner, Biochim., 70(2), 221–226 (1988).CrossRefGoogle Scholar
  16. 16.
    B. J. Berne and R. Pecora, Dynamic Light Scattering with applications to Chemistry, Biology and Physics. Dover Publ., INC, New York (2000).Google Scholar
  17. 17.
    É. V. Frisman, L. V. Schagina, and V. I. Vorob’ev, Biorheology, 2, 189 (1965).Google Scholar
  18. 18.
    V. N. Tsvetkov, V. E. Éskin, and S. Ya. Frenkel’, Statistics of Macromolecules in Solutions [in Russian], Nauka, Moscow (1964).Google Scholar
  19. 19.
    É. V. Frisman, M. A. Sibileva, and A. V. Krasnoperova, Vysokomol. Soed., 1, 597–606 (1962).Google Scholar
  20. 20.
    N. A. Kas’yanenko, A. Zanina, O. Nazarova, and E. Panarin, Langmuir, 15, 7912 (1999).CrossRefGoogle Scholar
  21. 21.
    N. A. Kas’yanenko, A. Zanina, L. Plotnikova, et al., Macromol. Symp., 136, 25 (1998).Google Scholar
  22. 22.
    N. A. Kas’yanenko, M. A. Karymov, N. A. Smorygo, et al., Molekulyar. Bio., 29, 585 (1995)Google Scholar
  23. 23.
    N. A. Kas’yanenko, N. Arikainen, and É. Frisman, Biophys. Chem., 70, 93 (1998).CrossRefGoogle Scholar
  24. 24.
    S. Y. Park, D. Harries, and W. M. Gelbart, Biophys. J., 75 (1998).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • N. A. Kas’yanenko
    • 1
  • D. A. Afanasieva
    • 1
  1. 1.St. Petersburg State UniversitySt. Petersburg

Personalised recommendations