The Journal of Primary Prevention

, Volume 33, Issue 4, pp 153–159 | Cite as

Community-Responsive Interventions to Reduce Cardiovascular Risk in American Indians

  • Jared B. Jobe
  • Alexandra K. Adams
  • Jeffrey A. Henderson
  • Njeri Karanja
  • Elisa T. Lee
  • Karina L. Walters
Literature Review


American Indian and Alaska Native (AI/AN) populations bear a heavy burden of cardiovascular disease (CVD), and they have the highest rates of risk factors for CVD, such as cigarette smoking, obesity, and diabetes, of any U.S. population group. Yet, few randomized controlled trials have been launched to test potential preventive interventions in Indian Country. Five randomized controlled trials were initiated recently in AI/AN communities to test the effectiveness of interventions targeting adults and/or children to promote healthy behaviors that are known to impact biological CVD risk factors. This article provides a context for and an overview of these five trials. The high burden of CVD among AI/AN populations will worsen unless behaviors and lifestyles affecting CVD risk can be modified. These five trials, if successful, represent a starting point in addressing these significant health disparities.


Behavioral risk for cardiovascular disease Diabetes Lifestyle changes 



These trials were supported by 5 cooperative agreements between the funding agency and the institutions of the principal investigators. The authors thank the community partners who collaborated in these trials.


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Copyright information

© Springer Science+Business Media, LLC (outside the USA)  2012

Authors and Affiliations

  • Jared B. Jobe
    • 1
  • Alexandra K. Adams
    • 2
  • Jeffrey A. Henderson
    • 3
  • Njeri Karanja
    • 4
  • Elisa T. Lee
    • 5
  • Karina L. Walters
    • 6
  1. 1.Division of Cardiovascular SciencesNational Heart, Lung, and Blood InstituteBethesdaUSA
  2. 2.Department of Family MedicineUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA
  3. 3.Black Hills Center for American Indian HealthRapid CityUSA
  4. 4.Center for Health ResearchKaiser PermanentePortlandUSA
  5. 5.Center for American Indian Health Research, College of Public HealthUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA
  6. 6.University of Washington Indigenous Wellness Research Institute and School of Social WorkSeattleUSA

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