Although ginsenoside Rg3 is very important in pharmaceutical field, the application of this drug is greatly limited by the release rate due to its poor dissolution. Here we introduced a meso/macroporous SiO2 to assist dispersing Rg3. The as-obtained SiO2/Rg3 (m/M-SiO2/Rg3) with this well-designed support showed superior Rg3 release rate compared to a mesoporous SiO2/Rg3 (m-SiO2/Rg3) at the same release duration and Rg3 loading 20 wt%. The excellent performance of the carrier drug could be attributed to the structural characteristics of hierarchically porous SiO2. On one hand, the macropores (~ 270 nm) accommodate for the active ingredient as effective reservoirs, more importantly the interconnected macropores efficiently shortens the paths of transferring Rg3, which facilitates releasing Rg3 at the nearest mesoporous channels (~ 2.8 nm) penetrated on the wall of adjacent macropores.
This is a preview of subscription content, access via your institution.
We’re sorry, something doesn't seem to be working properly.
Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.
A.S. Wong, C.M. Che, K.W. Leung, Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview. Nat. Product Rep. 32(2), 256–272 (2015)
X. Zheng, W. Chen, H. Hou et al., Ginsenoside 20(S)-Rg3 induced autophagy to inhibit migration and invasion of ovarian cancer. Biomed. Pharmacother. 85, 620–626 (2017)
T. Wang, R. Guo, G. Zhou, et al., Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.) F.H. Chen: a review. J. Ethnopharmacol. 188, 234–258 (2016).
Y. Jing, S. Li, L. Wang et al., Ginsenoside Rg3 attenuates lipopolysaccharide-induced acute lung injury via MerTK-dependent activation of the PI3K/AKT/mTOR pathway. Front. Pharmacol. 9, 850 (2018)
S. Kang, S.J. Park, A.Y. Lee et al., Ginsenoside Rg3 promotes inflammation resolution through M2 macrophage polarization. J. Ginseng Res. 42(1), 68–74 (2018)
A. Kang, T. Xie, D. Zhu et al., Suppressive effect of ginsenoside Rg3 against lipopolysaccharide-induced depression-like behavior and neuroinflammation in mice. J. Agric. Food Chem. 65(32), 6861–6869 (2017)
M.H. Lahiani, S. Eassa, C. Parnell et al., Carbon nanotubes as carriers of Panax ginseng metabolites and enhancers of ginsenosides Rb1 and Rg1 anti-cancer activity. Nanotechnology 28(1), 015101 (2017)
C. Tang, Y. Wang, Y. Long et al., Anchoring 20(R)-ginsenoside Rg3 onto cellulose nanocrystals to increase the hydroxyl radical scavenging activity. ACS Sustain. Chem. Eng. 5(9), 7507–7513 (2017)
Q. Zhang, X. Kang, B. Yang et al., Antiangiogenic effect of capecitabine combined with ginsenoside Rg3 on breast cancer in mice. Cancer Biother. Radiopharm. 23(5), 647–653 (2008)
M. Han, L. Ma, X. Yu et al., A nanoparticulate drug-delivery system for 20(S)-protopanaxadiol: formulation, characterization, increased oral bioavailability and anti-tumor efficacy. Drug Deliv. 23(7), 1–9 (2015)
W. Pudło, P. Przemysław et al., Hierarchical silica monolithic tablets as novel carriers for drug delivery. Eur. J. Pharm. Biopharm. 141, 12–20 (2019)
H. Cheng, X. Fan, X. Wang et al., Hierarchically self-assembled supramolecular host-guest delivery system for drug resistant cancer therapy. Biomacromolecules 19(6), 1926–1938 (2018)
Q. Jin, F. Qu, J. Jiang et al., A pH-sensitive controlled dual-drug release from meso-macroporous silica/multilayer-polyelectrolytes coated SBA-15 composites. J. Sol-Gel Sci. Technol. 66(3), 466–471 (2013)
Y. Zhang, H. Wang, C. Li et al., A Novel three-dimensional large-pore mesoporous carbon matrix as a potential nanovehicle for the fast release of the poorly water-soluble drug. Celecoxib. Pharm. Res. 31(4), 1059–1070 (2014)
M. Prokopowicz, J. Żeglinski et al., Surface-activated fibre-like SBA-15 as drug carriers for bone diseases. Aaps Pharm. 20(1), 1–13 (2018)
A. Maleki, M. Hamidi, Dissolution enhancement of a model poorly water-soluble drug, atorvastatin, with ordered mesoporous silica: comparison of MSF with SBA-15 as drug carriers. Expert Opin. Drug Deliv. 13(2), 171–181 (2016)
T. Heikkil, J. Salonen, J. Tuura et al., Mesoporous silica material TUD-1 as a drug delivery system. Int. J. Pharm. 331(1), 133–138 (2007)
Y. Hu, Z. Zhi, Q. Zhao et al., 3D cubic mesoporous silica microsphere as a carrier for poorly soluble drug carvedilol. Microporous Mesoporous Mater. 147(1), 94–101 (2012)
B.T. Holland, C.F. Blanford, T. Do et al., Synthesis of highly ordered, three-dimensional, macroporous structures of amorphous or crystalline inorganic oxides, phosphates, and hybrid composites. Chem. Mater. 11(3), 795–805 (1999)
D. Zhao, Q. Huo, J. Feng et al., Nonionic triblock and star diblock copolymer and oligomeric surfactant syntheses of highly ordered, hydrothermally stable, mesoporous silica structures. J. Am. Chem. Soc. 120(24), 6024–6036 (1998)
M.V. Speybroeck, V.R. Barillaro, T.D. Thi et al., Ordered mesoporous silica material SBA-15: A broad-spectrum formulation platform for poorly soluble drugs. J. Pharm. Sci. 98(8), 2648–2658 (2010)
J.-P. Dacquin, A.F. Lee, K. Wilson et al., Hierarchical macroporous–mesoporous SBA-15 sulfonic acid catalysts for biodiesel synthesis. Green Chem. 12(2), 296–303 (2010)
P. Zhao, L. Wang, C. Sun et al., Uniform mesoporous carbon as a carrier for poorly water soluble drug and its cytotoxicity study. Eur. J. Pharm. Biopharm. 80(3), 535–543 (2012)
C. Govindasamy, W.J. Son et al., Synthesis of mesoporous materials SBA-15 and CMK-3 from fly ash and their application for CO2 adsorption. J. Porous Mater. 16(5), 545–551 (2009)
B. Liu, R.T. Baker, Factors affecting the preparation of ordered mesoporous ZrO2 using the replica method. J. Mater. Chem. 18(43), 5200–5207 (2008)
B.C. Hancock, M. Parks, What is the true solubility advantage for amorphous pharmaceuticals? Pharm. Res. 17(4), 397–404 (2000)
D.R. Rolison, Catalytic nanoarchitectures-the importance of nothing and the unimportance of periodicity. Science 299(5613), 1698–1701 (2003)
Y. Liu acknowledges the support from National key research and development funding (2018YFC1707000).
Conflict of interest
The authors declare no conflict of interest.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Below is the link to the electronic supplementary material.
About this article
Cite this article
Wu, M., Xu, J., Lin, X. et al. Enhanced release rate of the poorly water-soluble ginsenoside Rg3 with ordered meso/macroporous silica. J Porous Mater (2021). https://doi.org/10.1007/s10934-020-01025-5
- Ordered meso
- Macroporous drug
- Hierarchical structure
- Dissolution rate
- Ginsenoside Rg3