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A composite monolithic column fabricated with functionalized nanodiamond and its application in separation of small molecules

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Abstract

A nanodiamond-based composite monolithic column was fabricated by redox initiation for high performance liquid chromatography (HPLC). The functionalized nanodiamond was modified via Fenton Reagent and 3-methacryl oxypropyltrimethoxysilane (KH-570). After being optimized conditions, composite monolithic columns were prepared with functionalized ND (f-ND) as functional monomer, dipentaerythritol hexaacrylate and ethylene dimethacrylate as crosslinking agents, dodecanol and 1-propanol as co-porogens, dibenzoyl peroxide and N,N-dimethyl aniline as initiators. Characterizations of the resulting nanocomposite, including fourier transform infrared spectra, scanning electron microscopy images, thermal gravimetric analysis, mercury intrusion porosimetry and nitrogen adsorption–desorption isotherm were all carried out in detail. Bigger specific surface area, better mechanical stability, thermostability property and orderliness skeleton structure with flow-through channels and macroporous of the composite monolithic column was exhibited than those columns without f-ND added. At last, the nanodiamond-based composite monolithic column was used to separate a series of small molecules including acidic, alkaline and neutral compounds with good resolution and reproducibility in HPLC.

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Acknowledgments

The study was funded by the National Natural Science Foundation of China (No. 21175031, 21575033, 21505030), the Natural Science Foundation of Hebei Province (No. B2013201082, B2015201024) and the Natural Science Foundation of Hebei University (No. 2014-05).

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Authors and Affiliations

  1. Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding, 071002, China

    Aile Wei, Peipei Dong, Beijiao Cui, Fengqing Wang, Haiyan Liu, Ligai Bai & Hongyuan Yan

  2. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding, 071002, China

    Aile Wei, Peipei Dong, Beijiao Cui, Fengqing Wang, Haiyan Liu, Ligai Bai & Hongyuan Yan

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  1. Aile Wei
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  2. Peipei Dong
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  3. Beijiao Cui
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  4. Fengqing Wang
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  5. Haiyan Liu
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  6. Ligai Bai
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  7. Hongyuan Yan
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Correspondence to Haiyan Liu.

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Wei, A., Dong, P., Cui, B. et al. A composite monolithic column fabricated with functionalized nanodiamond and its application in separation of small molecules. J Porous Mater 24, 373–380 (2017). https://doi.org/10.1007/s10934-016-0270-4

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  • DOI: https://doi.org/10.1007/s10934-016-0270-4

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