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Formulation and Evaluation of Matrix Type Transdermal Patch Containing Silver Nanoparticles

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Abstract

This research aimed to prepare the silver nanoparticles (AgNPs)-loaded antimicrobial wound dressing patch using ethyl cellulose as a matrix membrane and diethyl phthalate as a plasticizer. The polymer suspension was homogeneously mixed with plasticizer, and then added to the colloidal AgNPs suspension. This mixture was poured into Petri dish and subsequently dried in a hot air oven at 80 ± 2 °C for 10 h. The minimum inhibition concentration of the colloidal AgNPs suspension was 2.5 µg/ml. The AgNPs-loaded antimicrobial wound dressing patch was evaluated for physical properties by differential scanning calorimeter, X-ray diffraction, scanning electron microscope, and in vitro study. The antimicrobial wound dressing patch did not exhibit any interaction between the matrix membrane and AgNPs. The AgNPs were evenly dispersed in the patch. The patch could control the release of silver at 102.98 ± 4.11% over 12 h. Although the AgNPs-loaded antimicrobial wound dressing patches can be easily prepared by the simple method, in future studies antimicrobial wound dressing patch will be developed by employing different types of film forming agents.

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Acknowledgements

The authors would like to acknowledge the Faculty of Pharmacy and the Research Institute of Rangsit University for Financial Support.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, College of Pharmacy, Rangsit University, Muang, Pathum Thani, 12000, Thailand

    Jirapornchai Suksaeree, Akkharakunya Thuengernthong, Kanchala Pongpichayasiri & Pattwat Maneewattanapinyo

  2. The Herbal Medicinal Products Research and Development Center, College of Pharmacy, Rangsit University, Muang, Pathum Thani, 12000, Thailand

    Sukanya Settharaksa

  3. Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, 90112, Thailand

    Wiwat Pichayakorn

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  1. Jirapornchai Suksaeree
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  2. Akkharakunya Thuengernthong
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  3. Kanchala Pongpichayasiri
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  6. Wiwat Pichayakorn
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Correspondence to Jirapornchai Suksaeree or Pattwat Maneewattanapinyo.

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Suksaeree, J., Thuengernthong, A., Pongpichayasiri, K. et al. Formulation and Evaluation of Matrix Type Transdermal Patch Containing Silver Nanoparticles. J Polym Environ 26, 4369–4375 (2018). https://doi.org/10.1007/s10924-018-1305-5

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  • DOI: https://doi.org/10.1007/s10924-018-1305-5

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