Toward Effective Vaccine Deployment: A Systematic Study
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Vaccination is a commonly-used epidemic control strategy based on direct antiviral immunization and indirect reduction of virus transmissibility. There exist three factors related to the efficacy of vaccine deployment; they are: (1) vaccine coverage, (2) releasing time, and (3) deployment method. Yet, the exact impacts of these factors still remain to be systematically studied. In our work, we examine the effectiveness of vaccination-based epidemic control in adjusting the composition of susceptible and infectious individuals (referred to as composite structure) in a host population. We develop a modified compartmental infection model for characterizing virus spreading dynamics in several age-specific host populations (one host population for each age group). We consider vaccine deployment schedules that correspond to different settings of the three deployment factors. Based on our simulation-based experiments, we evaluate the impacts of deployment factors on virus spreading dynamics as well as their implications for an effective vaccination strategy.
KeywordsEpidemic control H1N1 influenza Vaccine deployment strategy Age-specific compartmental model
The authors would like to thank Chao Gao, Lailei Huang, Benyun Shi and Tao Li of the Autonomy-Oriented Computing (AOC) Research Group at Hong Kong Baptist University for their proofreading.
- 1.WHO. World Now at The Start of 2009 Influenza Pandemic; 2009. Accessed October 11, 2010. http://www.who.int/mediacentre/news/statements/2009.
- 2.WHO. Weekly Update: Pandemic (H1N1) 2009 - update 112; 2010. Accessed October 11, 2010. http://www.who.int/csr/don/2010_08_06/en/index.html.
- 3.Liu J, Xia S. ACM SIGHIT. Effective Epidemic Control via Strategic Vaccine Deployment: A Systematic Approach. Proceeding Health Informatics Symposium (IHI’10). 2010 Novermber; p. 91–99.Google Scholar
- 4.Grassly NC, Fraser C. Mathematical Models of Infectious Disease Transmission. Nature Reviews Microbiology. 2008 Jun;6(6):477–487.Google Scholar
- 5.Diekmann O, Heesterbeek JAP. Mathematical Epidemiology of Infectious Diseases: Model Building, Analysis and Interpretation. Wiley; 2000.Google Scholar
- 6.Daley DJ, Gani JM. Epidemic Modelling: An Introduction. Cambridge University Press; 2000.Google Scholar
- 7.Anderson RM, May RM. Infectious Diseases of Humans: Dynamics and Control. Oxford University Press; 1992.Google Scholar
- 8.Barrat A, Barthelemy M. Dynamical Processes on Complex Networks. Cambridge University Press; 2008.Google Scholar
- 10.Newman MEJ. The Spread of Epidemic Disease on Networks. Physical Review. 2002;66(1).Google Scholar
- 12.Gao C, Liu J, Zhong N. Network Immunization with Distributed Autonomy-oriented Entities. IEEE Transactions on Parallel and Distributed Systems. 2010.Google Scholar
- 14.Centers for Disease Control and Prevention. 2009 H1N1 Vaccination Recommendations. http://www.cdc.gov/h1n1flu/vaccination/acip.htm.
- 15.Center for Health Protection. Prevention of Human Swine Influenza. http://www.chp.gov.hk/en/view_content/16615.html.
- 17.Medlock J, Meyers LA, Galvani A. Optimizing Allocation for a Delayed Influenza Vaccination Campaign. PLoS Currents Influenza. 2009;1(RRN1134).Google Scholar
- 23.Statistical Tables of the 2006 Hong Kong Population By-census. http://www.bycensus2006.gov.hk/en/data/data3/index.htm.