Journal of Medical Systems

, Volume 30, Issue 2, pp 123–132 | Cite as

Enhancing the Utility of ProstaScint SPECT Scans for Patient Management

  • Marilyn E. Noz
  • Grace Chung
  • Benjamin Y. Lee
  • Gerald Q. MaguireJr.
  • J. Keith DeWyngaert
  • Jay V. Doshi
  • Elissa L. Kramer
  • Antoinette D. Murphy-Walcott
  • Michael P. Zeleznik
  • Noeun G. Kwak
Research Article


This project investigated reducing the artifact content of In-111 ProstaScint SPECT scans for use in treatment planning and management. Forty-one patients who had undergone CT or MRI scans and simultaneous Tc-99m RBC/In-111 ProstaScint SPECT scans were included. SPECT volume sets, reconstructed using Ordered Set-Expectation Maximum (OS-EM) were compared against those reconstructed with standard Filtered Back projection (FBP). Bladder activity in Tc-99m scans was suppressed within an ellipsoidal volume. Tc-99m voxel values were subtracted from the corresponding In-111 after scaling based on peak activity within the descending aorta. The SPECT volume data sets were merged with the CT or MRI scans before and after processing. Volume merging, based both on visual assessment and statistical evaluation, was not affected. Thus iterative reconstruction together with bladder suppression and blood pool subtraction may improve the interpretation and utility of ProstaScint SPECT scans for patient management.


Reconstruction algorithms ProstaScint SPECT artifact elimination Volume fusion Volume subtraction Prostate cancer treatment planning. 


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Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • Marilyn E. Noz
    • 1
  • Grace Chung
    • 1
  • Benjamin Y. Lee
    • 1
  • Gerald Q. MaguireJr.
    • 2
  • J. Keith DeWyngaert
    • 3
  • Jay V. Doshi
    • 1
  • Elissa L. Kramer
    • 1
  • Antoinette D. Murphy-Walcott
    • 1
  • Michael P. Zeleznik
    • 4
  • Noeun G. Kwak
    • 5
  1. 1.Department of RadiologyNYU School of MedicineNew York
  2. 2.School of Information and Communication TechnologyKistaSweden
  3. 3.Department of Radiation OncologyNYU School of MedicineNew York
  4. 4.RAHD Oncology ProductsSt. Louis
  5. 5.UMDNJ – Robert Wood Johnson Medical SchoolPiscataway

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