Intraductal Therapy in Breast Cancer: Current Status and Future Prospective

Abstract

With our improved understanding of the biological behavior of breast cancer, minimally invasive intervention is urgently needed for personalized treatment of early disease. Intraductal therapy is one such minimally invasive approach. With the help of appropriate tools, technologies using the intraductal means of entering the ducts may be used both to diagnose and treat lesions in the mammary duct system with less trauma and at the same time avoid systemic toxicity. Traditional agents such as those targeting pathways, endocrine therapy, immunotherapy, or gene therapy can be used alone or combined with other new technologies, such as nanomaterials, through the intraductal route. Additionally, relevant mammary tumor models in rodents which reflect changes in the tumor microenvironment will help deepen our understanding of their biological behavior and heterogeneity. This article reviews the current status and future prospects of intraductal therapy in breast cancer, with emphasis on ductal carcinoma in situ.

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Availability of Data and Material

The datasets used and/or analyzed during the current study are available from the corresponding author for reasonable requests.

Funding

This research was supported by grants from the Fundamental Research Funds for the Central Universities (2042019kf0229), the Science and Technology Major Project of Hubei Province (Next-Generation AI Technologies) (2019AEA170), the National Natural Science Foundation of China (81802895) and by the Fetting Fund.

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Xin-Wen Kuang and Zhi-Hong Sun collected and analyzed relevant literature. Jian-Hua Liu and Xin-Wen Kuang drafted the manuscript. Chuang Chen, Saraswati Sukumar and Sheng-Rong Sun critically revised the manuscript for content. All authors read and approved the final manuscript.

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Correspondence to Chuang Chen.

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Kuang, X., Liu, J., Sun, Z. et al. Intraductal Therapy in Breast Cancer: Current Status and Future Prospective. J Mammary Gland Biol Neoplasia (2020). https://doi.org/10.1007/s10911-020-09453-4

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Keywords

  • Breast cancer
  • Intraductal therapy
  • Minimally invasive
  • Personalized therapy
  • Nanomedicine
  • Ductal carcinoma in situ