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Serotonin and Serotonin Transport in the Regulation of Lactation

  • Aaron M. Marshall
  • Laura L. Hernandez
  • Nelson D. Horseman
Article

Abstract

Serotonin (5-HT), classically known as a neurotransmitter involved in regulating sleep, appetite, memory, sexual behavior, neuroendocrine function and mood is also synthesized in epithelial cells located in many organs throughout the body, including the mammary gland. The function of epithelial 5-HT is dependent on the expression of the 5-HT receptors in a particular system. The conventional components of a classic 5-HT system are found within the mammary gland; synthetic enzymes (tryptophan hydroxylase I, aromatic amino acid decarboxylase), several 5-HT receptors and the 5-HT reuptake transporter (SERT). In the mammary gland, two actions of 5-HT through two different 5-HT receptor subtypes have been described: negative feedback on milk synthesis and secretion, and stimulation of parathyroid hormone related-protein, a calcium-mobilizing hormone. As with neuronal systems, the regulation of 5-HT activity is multifactorial, but one seminal component is reuptake of 5-HT from the extracellular space following its release. Importantly, the wide availability of selective 5-HT reuptake inhibitors (SSRI) allows the manipulation of 5-HT activity in a biological system. Here, we review the role of 5-HT in mammary gland function, review the biochemistry, genetics and physiology of SERT, and discuss how SERT is vital to the function of the mammary gland.

Keywords

Epithelium Involution PTHrP SSRI Tight junctions 

Abbreviations

5-HT

serotonin

SERT

serotonin transporter

SSRI

selective serotonin reuptake inhibitor

5-HTP

5-hydroxy-L-tryptophan

TPH

tryptophan hydroxylase

AADC

aromatic amine decarboxylase

MAO

monoamine oxidase

5-HIAA

5-hydroxyindole acetic acid

RANKL

receptor activator of NF-κB ligand

PTHrP

parathyroid hormone related protein

VMAT

vesicular monoamine transporters

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Aaron M. Marshall
    • 1
  • Laura L. Hernandez
    • 2
  • Nelson D. Horseman
    • 3
  1. 1.Department of Medical EducationUniversity of CincinnatiCincinnatiUSA
  2. 2.Department of Dairy ScienceUniversity of WisconsinMadisonUSA
  3. 3.Department of Molecular and Cellular Physiology, Program in Systems Biology and PhysiologyUniversity of CincinnatiCincinnatiUSA

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