Journal of Mammary Gland Biology and Neoplasia

, Volume 16, Issue 3, pp 247–256 | Cite as

Oncogene-Induced Senescence and its Role in Tumor Suppression

  • Jay P. Reddy
  • Yi Li


While senescence has been known for some time as an inevitable result of repeated DNA replication, oncogene-induced senescence (OIS) represents a relatively new phenomenon. OIS, like apoptosis, has emerged to represent a putative barrier to tumorigenesis in many tissues, including the breast. Here we discuss signals that initiate OIS, evidence for its role in tumor suppression, and mechanisms for its evasion in tumorigenesis.


Senescence Oncogene-induced senescence Breast cancer Anticancer barrier DDR 



atypical ductal hyperplasias


ataxia telangiectasia mutated


ataxia telangiectasia and Rad3 related


chemokine receptor 2


decoy receptor 2


DNA Damage Response


ductal carcinoma in situ


differentiated embryo chondrocyte expressed gene 1


double-strand break


epithelial-mesenchymal transition


histone H3 di- or tri-methylated on lysine 9


high mobility group protein A2


heterochromatin protein 1γ


insulin-like growth factor-binding protein 7


ionizing radiation


matrix metalloproteinase 3


mouse mammary tumor virus




oncogene-induced senescence


plasminogen activator inhibitor-1


intraepithelial neoplasias


replication competent ALV-LTR, splice receptor


replication factor C


reactive oxygen species


replication protein A


senescence-associated heterochromatin foci


senescence-associated secretory phenotype


single-strand break


senescence-associated β-galactosidase


tumor virus A



We thank Drs. Pumin Zhang and Gary Chamness for critical review of this manuscript. This work was supported in part by funds from USAMRMC BC030755 (to Y.L.) and BC073703 (to Y.L.) and from National Institutes of Health CA124820 (to Y.L.). J.P.R. was supported by the Robert and Janice McNair Foundation and a CDMRP pre-doctoral fellowship (BC083190).


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Molecular & Cellular BiologyBaylor College of MedicineHoustonUSA
  2. 2.Lester and Sue Smith Breast Center, Baylor College of MedicineHoustonUSA

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