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Journal of Mammary Gland Biology and Neoplasia

, Volume 15, Issue 3, pp 329–339 | Cite as

Immune Cell Location and Function During Post-Natal Mammary Gland Development

  • Johanna R. Reed
  • Kathryn L. Schwertfeger
Article

Abstract

Post-natal mammary gland development requires complex interactions between the epithelial cells and various cell types within the stroma. Recent studies have illustrated the importance of immune cells and their mediators during the various stages of mammary gland development. However, the mechanisms by which these immune cells functionally contribute to mammary gland development are only beginning to be understood. This review provides an overview of the localization of immune cells within the mammary gland during the various stages of post-natal mammary gland development. Furthermore, recent studies are summarized that illustrate the mechanisms by which these cells are recruited to the mammary gland and their functional roles in mammary gland development.

Keywords

Mammary gland Immune cell Immune mediator Macrophage Mast cell Eosinophil 

Abbreviations

TGFβ

Transforming growth factor β

TNFα

Tumor necrosis factor α

IL

Interleukin

PMN

Polymorphonuclear leukocytes

TGFα

Transforming growth factor α

EGF

Epidermal growth factor

Th1

T helper cell 1

Th2

T helper cell 2

IFNγ

Interferon-γ

TEB

Terminal end bud

CLA

Conjugated linoleic acid

Csf1

Colony-stimulating factor 1

MMTV

Mouse mammary tumor virus

Tg

Transgenic

NGF

Nerve growth factor

CSF-1R

Colony stimulating factor 1 receptor

IgA

Immunoglobulin A

VCAM-1

Vascular cell adhesion molecule-1

Notes

Acknowledgements

The authors would like to thank Dr. Jodi Goldberg for critical reading of this manuscript. JRR is supported by a pre-doctoral fellowship on the T32 CA009138 Cancer Biology Training Grant.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Lab Medicine and Pathology, Graduate Program in Microbiology, Immunology and Cancer Biology, Masonic Cancer CenterUniversity of MinnesotaMinneapolisUSA

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