Roles of the Innate Immune System in Mammary Gland Remodeling During Involution
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Mammary gland involution is a period of intensive tissue remodeling. Over the course of a relatively brief period, a large proportion of the mammary gland epithelium undergoes programmed cell death and is removed by phagocytes. In addition, the gland is cleared of residual milk fat globules as well as milk and adipocytes become the predominant cell type. The role of the immune system in this process has not been clearly defined. Professional phagocytes derived from the immune system can participate in the clearance of apoptotic and autophagic cells, the removal of residual milk components, and the prevention of mastitis during mammary gland involution. However, many of these functions can also be performed by non-professional phagocytes (e.g. mammary epithelial cells). This review will discuss the evidence that supports a role for innate immune cells in mammary gland remodeling during involution.
KeywordsInvolution Mammary gland Phagocytosis Innate immunity Remodeling
mammary epithelial cells
programmed cell death
The authors were supported by funds HL64353, HL56385, and HL53949 from the National Heart, Lung, and Blood Institute (D.S.), CA57621 from the National Cancer Institute and ES12801 from the National Institute of Environmental Health Sciences and the National Cancer Institute (Z.W.), and a National Institutes of Health fellowship 1F32 HL073530-01 (K.A.).
- 18.Hughes J, Liu Y, Van Damme J, Savill J. Human glomerular mesangial cell phagocytosis of apoptotic neutrophils: mediation by a novel CD36-independent vitronectin receptor/thrombospondin recognition mechanism that is uncoupled from chemokine secretion. J Immunol 1997;158(9):4389–97.PubMedGoogle Scholar
- 36.Rodriguez-Manzaneque JC, Lane TF, Ortega MA, Hynes RO, Lawler J, Iruela-Arispe ML. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc Natl Acad Sci USA 2001;98(22):12485–90.PubMedCrossRefGoogle Scholar
- 66.Fioretti F, Fradelizi D, Stoppacciaro A, Ramponi S, Ruco L, Minty A, et al. Reduced tumorigenicity and augmented leukocyte infiltration after monocyte chemotactic protein-3 (MCP-3) gene transfer: perivascular accumulation of dendritic cells in peritumoral tissue and neutrophil recruitment within the tumor. J Immunol 1998;161(1):342–6.PubMedGoogle Scholar