Milking Biological Diversity For All It’s Worth—What Do Other Model Systems Teach Us About Mammary Gland Development and Function?

  • Lindsay Hinck
  • Michael T. Lewis
  • Sean E. Egan

The basic processes involved in development of the functional mammary gland are each related to processes used to develop structures in other organ systems of the mammal. Indeed, many of these processes also occur in lower vertebrates and in invertebrates. Consequently, the mammary developmental biology community can, and does, benefit from comparing our system to others. Testable hypotheses are continually generated to explain aspects of mammary development and physiology based on work in other developmental systems. In this issue of Journal of Mammary Gland Biology & Neoplasia, six mammary processes are explored through comparison with other systems, ranging from branching morphogenesis and lumen formation in the fly, to exocrine secretion in the pancreas.

The first step towards formation of a mammary gland is specification and invagination of a mammary bud. Mikkola and Millar provide a unique perspective on this process by comparing it to the formation and early development of other...


Mammary Gland Mammary Development Mammary Gland Development Lumen Formation Ductal Tree 
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Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Lindsay Hinck
    • 1
  • Michael T. Lewis
    • 2
  • Sean E. Egan
    • 3
    • 4
  1. 1.Department of Molecular, Cell and Developmental Biology 225 Sinsheimer LaboratoryUniversity of California, Santa CruzSanta CruzUSA
  2. 2.Baylor College of MedicineHoustonUSA
  3. 3.Program in Developmental BiologyThe Hospital for Sick ChildrenTorontoCanada
  4. 4.Department of Molecular and Medical GeneticsThe University of TorontoTorontoCanada

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