Journal of Mathematical Chemistry

, Volume 48, Issue 3, pp 635–652 | Cite as

A general model for non-autocatalytic zymogen activation in the presence of two different and mutually exclusive inhibitors. II. Relative weight of activation and inhibition processes

  • J. Masiá-Pérez
  • J. Escribano
  • E. Valero
  • E. Arribas
  • M. García-Moreno
  • J. L. Muñoz-Muñoz
  • R. Gómez-Ladrón de Guevara
  • R. Varón
Original Paper


The kinetic study carried out in paper I of this series (preceding article) on enzyme systems involving zymogen activation and the simultaneous action of two different, mutually exclusive inhibitors (Scheme 1) allows, new dimensionless kinetic parameters to be suggested. These parameters furnish quantitative information about the relative weight of the activation and inhibition routes, i.e. the conditions under which the activation prevails over the inhibition and vice versa, as well as the absolute and relative contributions to overall inhibition of each of the inhibition routes and their synergistic effect. These results can be easily and directly applied to any of the thousands of particular cases of the model. Examples are given for different particular cases.


Enzyme kinetics Zymogen activation Enzymatic inhibition Relative weight Exclusive 


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • J. Masiá-Pérez
    • 1
  • J. Escribano
    • 2
  • E. Valero
    • 3
  • E. Arribas
    • 4
  • M. García-Moreno
    • 3
  • J. L. Muñoz-Muñoz
    • 5
  • R. Gómez-Ladrón de Guevara
    • 2
  • R. Varón
    • 3
  1. 1.Servicio de CardiologíaComplejo Hospitalario Universitario de AlbaceteAlbaceteSpain
  2. 2.Departamento de Ciencia y Tecnología Agroforestal y GenéticaUniversidad de Castilla-La ManchaAlbaceteSpain
  3. 3.Departamento de Química-FísicaUniversidad de Castilla-La ManchaAlbaceteSpain
  4. 4.Departamento de Física AplicadaUniversidad de Castilla-La ManchaAlbaceteSpain
  5. 5.Departamento de Bioquímica y Biología Molecular AUniversidad de MurciaMurciaSpain

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