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A pH-Responsive Molecularly Imprinted Hydrogel for Dexamethasone Release

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Abstract

A new type of pH-responsive molecularly imprinted polymer (MIP) hydrogel was reported, which can well control the release of dexamethasone sodium phosphate (DXP). The MIP hydrogel were prepared by precipitation polymerization using dopamine acrylamide (DPA) and acrylic acid (AAc) as functional monomers and DXP as the template molecule. The synthesized MIP hydrogel were characterized by SEM and FT-IR spectrometer. The rates of drug loading and drug release were determined by UV spectroscopy analysis. The results showed that the drug loading rate of MIP hydrogel was significantly higher than that of NIP hydrogel when immersed in different DXP solutions. Only 58% of the loaded drug released from MIP hydrogel in 24 h while the released drug exceed 80% for the NIP hydrogel, and such controlled slow release characteristics of MIP hydrogel sustained 7 days. Furthermore, the DXP-imprinted hydrogel exhibited pH-dependent due to the molecular interaction between the polymerized DPA and AAc.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 61471233, 21504051), the Program for Professor of Special Appointment (Eastern Scholar) at SIHL, Gaoyuan Discipline of Shanghai-Environmental Science and Engineering (Resource Recycling Science and Engineering) and the Graduate Program Foundation of Shanghai Polytechnic University (EGD17YJ0042).

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Authors and Affiliations

  1. School of Environmental and Materials Engineering, Shanghai Polytechnic University, 2360 Jinhai Road, Shanghai, 201209, China

    Pengju Wei, Runmin Song, Cheng Chen, Zhanhong Li & Zhigang Zhu

  2. Research Center of Resource Recycling Science and Engineering, Shanghai Polytechnic University, Shanghai, 201209, China

    Cheng Chen, Zhanhong Li & Zhigang Zhu

  3. School of Materials Science and Engineering, Jiangsu University, Zhenjiang, 212013, Jiangsu, China

    Songjun Li

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  1. Pengju Wei
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  2. Runmin Song
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  3. Cheng Chen
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  4. Zhanhong Li
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  5. Zhigang Zhu
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Correspondence to Zhigang Zhu or Songjun Li.

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Wei, P., Song, R., Chen, C. et al. A pH-Responsive Molecularly Imprinted Hydrogel for Dexamethasone Release. J Inorg Organomet Polym 29, 659–666 (2019). https://doi.org/10.1007/s10904-018-1039-9

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  • DOI: https://doi.org/10.1007/s10904-018-1039-9

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